Hours C, Vayssière Pia, Gressens P, Laforge M
Université Paris Cité, NeuroDiderot, Inserm, Paris, France.
Service de Neurochirurgie, Hôpital Fondation Adolphe de Rothschild, Paris, France.
J Neuroinflammation. 2025 Apr 28;22(1):122. doi: 10.1186/s12974-025-03440-4.
Immunity finely regulates brain function. It is directly involved in the pathological processes of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, post-stroke conditions, multiple sclerosis, traumatic brain injury, and psychiatric disorders (mood disorders, major depressive disorder (MDD), anxiety disorders, psychosis disorders and schizophrenia, and neurodevelopmental disorders (NDD)). Neuromodulation is currently a leading therapeutic strategy for the treatment of these disorders, but little is yet known about its immune impact on neuronal function and its precise beneficial or harmful consequences. We review relevant clinical and preclinical studies and identify several specific immune modifications. These data not only provide insights into how neuromodulation acts to optimize immune-brain interactions, but also pave the way for a better understanding of these interactions in pathological processes.
免疫精确调节大脑功能。它直接参与神经退行性疾病（如帕金森病和阿尔茨海默病）、中风后状况、多发性硬化症、创伤性脑损伤以及精神疾病（情绪障碍、重度抑郁症（MDD）、焦虑症、精神障碍和精神分裂症，以及神经发育障碍（NDD））的病理过程。神经调节目前是治疗这些疾病的主要治疗策略，但关于其对神经元功能的免疫影响及其确切的有益或有害后果，我们所知甚少。我们回顾了相关的临床和临床前研究，并确定了几种特定的免疫调节方式。这些数据不仅为理解神经调节如何优化免疫 - 脑相互作用提供了见解，也为更好地理解病理过程中的这些相互作用铺平了道路。
