Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Department of Statistics and Data Science, Yale University, New Haven, Connecticut, USA.
Crit Rev Food Sci Nutr. 2024;64(25):9113-9131. doi: 10.1080/10408398.2023.2208218. Epub 2023 May 4.
In the human body, the positive effects of phenolic compounds are increasingly observed through their presence in tissues and organs in their native form or in the form of metabolites or catabolites formed during digestion, microbial metabolism, and host biotransformation. The full extent of these effects is still unclear. The aim of this paper is to review the current knowledge of beneficial effects of native phenolic compounds or their metabolites and catabolites focusing on their role in the health of the digestive system, including disorders of the gastrointestinal and urinary tracts and liver. Studies are mostly connecting beneficial effects in the gastrointestinal and urinary tract to the whole food rich in phenolics, or to the amount of phenolic compounds/antioxidants in food. Indeed, the bioactivity of parent phenolic compounds should not be ignored due to their presence in the digestive tract, and the impact on the gut microbiota. However, the influence of their metabolites and catabolites might be more important for the liver and urinary tract. Distinguishing between the effects of parent phenolics metabolites and catabolites at the site of action are important for novel areas of food industry, nutrition and medicine.
在人体内，通过观察其在组织和器官中的天然形式或在消化、微生物代谢和宿主生物转化过程中形成的代谢物或分解产物中的存在，可以越来越多地观察到酚类化合物的积极作用。这些作用的全部范围尚不清楚。本文的目的是综述天然酚类化合物或其代谢物和分解产物的有益作用的现有知识，重点关注它们在消化系统健康中的作用，包括胃肠道和泌尿系统以及肝脏的紊乱。研究大多将胃肠道和泌尿系统的有益作用与富含酚类化合物的全食物或食物中的酚类化合物/抗氧化剂数量联系起来。事实上，由于酚类化合物存在于消化道中，以及对肠道微生物群的影响，不应忽视母体酚类化合物的生物活性。然而，它们的代谢物和分解产物对肝脏和泌尿系统的影响可能更为重要。区分母体酚类化合物、代谢物和分解产物在作用部位的作用，对于食品工业、营养和医学的新领域非常重要。
