Hinojosa-Nogueira Daniel, Díaz-Perdigones Cristina María, García-López María José, Marcos Ascensión, Portillo María P, Lamuela-Raventós Rosa María, Subiri-Verdugo Alba, Nova Esther, Milton-Laskibar Iñaki, Galkina Polina, Tinahones Francisco J, Moreno-Indias Isabel
Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma, BIONAND, 29590 Málaga, Spain.
Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.
Molecules. 2025 Jul 11;30(14):2932. doi: 10.3390/molecules30142932.
The consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled intervention with beer on (poly)phenols metabolism in individuals with and without metabolic syndrome (MetS). 20 participants (MetS and control) who consumed a standardized amount of beer during 6 weeks were recruited. Phenolic compounds were assessed in urine. Different changes in phenolic compounds associated with chronic beer consumption were found, particularly related to hesperetin conjugates and to the degradation of phenolic compounds derived from flavonoids and lignans. Noteworthily, MetS and control participants differed in baseline urine phenolic compound profiles and in their metabolization. Significant differences were found in the production and excretion of key (poly)phenols-derived metabolites, such as increased naringenin phase II conjugates in healthy subjects, or increased bacterial flavonoid catabolites. Certain relationships were observed between the phenolic compounds with metabolic and anthropometric variables. These findings suggest that beer-derived (poly)phenols are differentially metabolized according to metabolic-health status, and that they may contribute to certain metabolic health benefits through the modulation of specific metabolic pathways.
饮用低酒精发酵饮料与心血管健康改善有关。尽管其潜在机制尚未完全明确，但（多）酚类物质被认为是其中一种介导因素。本研究的目的是评估对有或无代谢综合征（MetS）的个体进行啤酒对照干预对（多）酚类物质代谢的影响。招募了20名参与者（代谢综合征患者和对照组），他们在6周内饮用了标准量的啤酒。对尿液中的酚类化合物进行了评估。发现与长期饮用啤酒相关的酚类化合物存在不同变化，特别是与橙皮素共轭物以及源自黄酮类化合物和木脂素的酚类化合物降解有关。值得注意的是，代谢综合征患者和对照组参与者在基线尿液酚类化合物谱及其代谢方面存在差异。在关键的（多）酚类物质衍生代谢产物的产生和排泄方面发现了显著差异，例如健康受试者中柚皮素II相共轭物增加，或细菌黄酮类分解代谢产物增加。观察到酚类化合物与代谢和人体测量变量之间存在某些关系。这些发现表明，源自啤酒的（多）酚类物质根据代谢健康状况进行不同的代谢，并且它们可能通过调节特定的代谢途径对某些代谢健康益处有所贡献。
