Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, CEP 59056-000, Natal, RN, Brasil.
Stomatologija. 2022;24(2):56-60.
Necrotizing sialometaplasia (NS) affects salivary glands, and despite being a benign condition, its clinical and histopathological features sometimes mimic other malignant pathologies of epithelial origin. This article presents two cases of NS and discusses clinicopathological features and the differential diagnosis of this condition. The first case, a 76-year-old woman with a 6-month history of painful oral thrush. Intraoral examination showed an ulcerative lesion located on the hard palate. The clinical hypothesis was squamous cell carcinoma. Second, a 26-year-old man with a 40-days ulcerative lesion on the soft palate. Intraoral examination revealed a reddish ulcer measuring 0.5 cm. Clinical hypothesis was traumatic ulcer. In both cases, a biopsy was performed, and a histopathological diagnosis of NS was established. NS cause is poorly understood, and its clinical features resemble other oral lesions with ulcerative aspects. Thus, dentists must be aware of the clinical features of oral ulcers with more than a 2-week duration without defined etiology.
坏死性涎腺化生（NS）影响唾液腺，尽管是良性的，但它的临床和组织病理学特征有时类似于其他上皮来源的恶性病变。本文介绍了两例 NS 病例，并讨论了这种疾病的临床病理特征和鉴别诊断。第一个病例是一名 76 岁女性，有 6 个月的口腔疼痛性鹅口疮病史。口腔检查显示硬腭上有一个溃疡性病变。临床假设是鳞状细胞癌。第二个病例是一名 26 岁男性，软腭上有一个 40 天的溃疡性病变。口腔检查显示一个 0.5 厘米大小的红色溃疡。临床假设是创伤性溃疡。在这两个病例中，都进行了活检，诊断为 NS。NS 的病因尚不清楚，其临床特征类似于其他具有溃疡性的口腔病变。因此，牙医必须注意口腔溃疡的临床特征，对于那些持续时间超过 2 周且无明确病因的溃疡尤其要注意。
