Janner Simone F M, Suter Valerie G A, Altermatt Hans Jörg, Reichart Peter A, Bornstein Michael M
Quintessence Int. 2014 May;45(5):431-7. doi: 10.3290/j.qi.a31543.
Necrotizing sialometaplasia (NS) is a rare and benign lesion that mostly affects the posterior hard palate. Its importance resides in its clinical and microscopic characteristics, which can closely mimic malignant neoplasias, in particular oral squamous cell carcinoma and mucoepidermoid carcinoma. Accurate histopathologic evaluation of an incisional biopsy is considered as the diagnostic gold standard. NS lesions heal spontaneously within weeks, and no further treatment is necessary. We report a case of a bilateral palatal NS in a 22-yearold woman with bulimia, where an incisional biopsy confirmed the clinical diagnosis. The different clinical stages of the lesions from onset to resolution and the possible etiologic factors are described in detail, as well as a discussion of the differential diagnoses of palatal ulcers. When taking a biopsy from suspicious oral lesions, care has to be taken that an appropriate tissue sample is harvested, and the histopathologic analysis is performed by an experienced pathologist to establish a correct diagnosis.
坏死性涎腺化生（NS）是一种罕见的良性病变，主要累及硬腭后部。其重要性在于其临床和微观特征，这些特征可与恶性肿瘤极为相似，尤其是口腔鳞状细胞癌和黏液表皮样癌。切开活检的准确组织病理学评估被视为诊断金标准。NS病变在数周内可自行愈合，无需进一步治疗。我们报告一例22岁患有贪食症的女性双侧腭部NS病例，切开活检证实了临床诊断。详细描述了病变从发病到消退的不同临床阶段以及可能的病因，还讨论了腭部溃疡的鉴别诊断。对可疑口腔病变进行活检时，必须注意获取合适的组织样本，并由经验丰富的病理学家进行组织病理学分析以确立正确诊断。
