Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan.
Jpn J Ophthalmol. 2023 Jul;67(4):382-386. doi: 10.1007/s10384-023-00992-x. Epub 2023 May 4.
To investigate blood monocyte counts as a risk factor for retinopathy of prematurity (ROP) treatment.
Retrospective cohort study.
Infants who underwent ROP screening at Shiga University of Medical Science Hospital between January, 2011 and July, 2021 were included in this study. Screening criteria were a gestational age (GA) < 32 weeks or birth weight (BW) < 1500 g. The week with the largest difference in monocyte counts between the infants with and without type 1 ROP determined based on the effect size. Multivariate logistic regression analysis was applied to investigate whether the monocyte counts constituted an independent risk factor for type 1 ROP. The objective variable was type 1 ROP, and the explanatory variables were GA, BW, infants' infection, and Apgar score at 1 min and monocyte counts in the week with the largest monocyte-counts difference between the with- and without type 1 ROP groups.
In total, 231 infants met the inclusion criteria. The monocyte counts in the fourth week after birth (4w MONO) exhibited the largest difference between infants with and without type 1 ROP. The analysis was performed on 198 infants, excluding 33 infants without 4w MONO data. Thirty-one infants had type 1 ROP, whereas 167 infants did not. BW and 4w MONO were significantly associated with type 1 ROP (odds ratio: 0.52 and 3.9, P < .001 and 0.004, respectively).
The 4w MONO was an independent risk factor for type 1 ROP and may be useful in follow-up of infants with ROP.
探讨血单核细胞计数是否为早产儿视网膜病变（ROP）治疗的危险因素。
回顾性队列研究。
本研究纳入了 2011 年 1 月至 2021 年 7 月在滋贺医科大学医院接受 ROP 筛查的婴儿。筛查标准为胎龄（GA）<32 周或出生体重（BW）<1500g。根据效应大小，确定单核细胞计数差值最大的那一周来判断有无 1 型 ROP。应用多变量逻辑回归分析来探讨单核细胞计数是否为 1 型 ROP 的独立危险因素。因变量为 1 型 ROP，自变量为 GA、BW、婴儿感染和 1 分钟时的 Apgar 评分以及有无 1 型 ROP 组单核细胞计数差值最大的那一周的单核细胞计数。
共有 231 名婴儿符合纳入标准。出生后第 4 周（4w MONO）的单核细胞计数在有无 1 型 ROP 的婴儿之间差异最大。在排除了 33 名无 4w MONO 数据的婴儿后，对 198 名婴儿进行了分析。31 名婴儿患有 1 型 ROP，而 167 名婴儿未患有 1 型 ROP。BW 和 4w MONO 与 1 型 ROP 显著相关（比值比：0.52 和 3.9，P<0.001 和 0.004）。
4w MONO 是 1 型 ROP 的独立危险因素，可能有助于 ROP 婴儿的随访。
