NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
Int J Oncol. 2023 Jun;62(6). doi: 10.3892/ijo.2023.5518. Epub 2023 May 5.
Under conditions of oxygen sufficiency, tumor cells supply themselves with energy through glycolysis, which is one of the causes of their rapid proliferation, metastasis and acquisition of drug resistance. Tumor‑associated macrophages (TAMs) are transformed from peripheral blood monocytes and are among the immune‑related cells that constitute the tumor microenvironment (TME). Altered glycolysis levels in TAMs have an important impact on their polarization and function. The cytokines secreted by TAMs, and phagocytosis in different polarization states, affect tumorigenesis and development. Furthermore, changes in glycolysis activity of tumor cells and other immune‑related cells in the TME also affect the polarization and function of TAMs. Studies on the relationship between glycolysis and TAMs have received increasing attention. The present study summarized the link between glycolysis of TAMs and their polarization and function, as well as the interaction between changes in glycolysis of tumor cells and other immune‑associated cells in the TME and TAMs. The present review aimed to provide a comprehensive understanding of the effects of glycolysis on the polarization and function of TAMs.
在氧充足的条件下，肿瘤细胞通过糖酵解为自身提供能量，这是其快速增殖、转移和获得耐药性的原因之一。肿瘤相关巨噬细胞（TAMs）由外周血单核细胞转化而来，是构成肿瘤微环境（TME）的免疫相关细胞之一。TAMs 中糖酵解水平的改变对其极化和功能有重要影响。TAMs 分泌的细胞因子和不同极化状态下的吞噬作用影响肿瘤的发生和发展。此外，TME 中肿瘤细胞和其他免疫相关细胞糖酵解活性的改变也会影响 TAMs 的极化和功能。关于糖酵解与 TAMs 之间关系的研究受到了越来越多的关注。本研究总结了 TAMs 的糖酵解与其极化和功能之间的联系，以及 TME 中肿瘤细胞和其他免疫相关细胞糖酵解的改变与 TAMs 之间的相互作用。本综述旨在全面了解糖酵解对 TAMs 极化和功能的影响。
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