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在经过认证的肿瘤中心接受治疗的晚期癌症患者中进行系统性症状筛查:前瞻性多中心德国 KeSBa 项目的结果。

Systematic symptom screening in patients with advanced cancer treated in certified oncology centers: results of the prospective multicenter German KeSBa project.

机构信息

Comprehensive Cancer Center, University Medical Center Göttingen, Göttingen, Germany.

Interdisciplinary Center Palliative Medicine, University Hospital Würzburg, Würzburg, Germany.

出版信息

J Cancer Res Clin Oncol. 2023 Sep;149(11):8829-8842. doi: 10.1007/s00432-023-04818-8. Epub 2023 May 5.

DOI:10.1007/s00432-023-04818-8
PMID:37145199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10374724/
Abstract

PURPOSE

Guidelines recommend a structured symptom screening (SC) for especially advanced cancer patients (CPs). The aim of this multicenter German prospective quality assurance project KeSBa (Kennzahl Symptom- und Belastungserfassung) was to gain knowledge on SC procedures in Oncology Centers (OCs) for advanced cancer patients and a first impression on the consequences of SC.

METHODS

The KeSBa project consisted of three phases: pilot, 3 months screening and feedback phase. Participating OCs decided to use either the Minimal Documentation System (MIDOS) or the Integrated Palliative care Outcome Scale (IPOS) and defined the cutoff values for positive screening results.

RESULTS

Out of 172 certified German OCs, 40 (23%) participated in the KeSBa pilot phase, 29 (16.8%) in the 3 months screening phase using MIDOS (n = 18, 58.6%) or IPOS (n = 11, 41.3%) and in the feedback round. 25/29 performed paper-based screening (86.2%). 2.963 CPs were screened. Results were documented for 1255 (42.2%, SC +) positive and 874 (29.5%, SC-) negative screenings depending on the center´s schedules: 452 SC + CPs (28.4%) and 42 SC- CPs (2.6%) had contact to specialized palliative care or other supportive specialist teams afterwards, 458 SC + CPs (28.8%) and 605 SC- CPs (38.1%) remained in standard oncology care. In the feedback round missing resources (personal and IT) and improved communication were mentioned most often.

CONCLUSION

Routine SC is feasible in advanced CPs treated in OCs but associated with considerable workload. In 42.2% of CPs SC was classified as positive, indicating the need of further diagnostics or professional judgment. SC requires staff and IT resources.

摘要

目的

指南建议对晚期癌症患者(CP)进行结构化症状筛查(SC)。本多中心德国前瞻性质量保证项目 KeSBa(症状和负担评估指标)的目的是了解肿瘤学中心(OC)对晚期癌症患者进行 SC 程序的知识,并对 SC 的结果有初步了解。

方法

KeSBa 项目分为三个阶段:试点、3 个月筛查和反馈阶段。参与的 OC 决定使用最小文档系统(MIDOS)或综合姑息治疗结局量表(IPOS),并定义阳性筛查结果的截断值。

结果

在 172 个获得认证的德国 OC 中,有 40 个(23%)参加了 KeSBa 试点阶段,29 个(16.8%)在使用 MIDOS(n=18,58.6%)或 IPOS(n=11,41.3%)的 3 个月筛查阶段和反馈轮次中进行了筛查。25/29 个进行了纸质筛查(86.2%)。共筛查了 2963 名 CPs。根据中心的时间表,对 1255 名(42.2%,SC+)阳性和 874 名(29.5%,SC-)阴性筛查结果进行了记录:452 名 SC+CPs(28.4%)和 42 名 SC-CPs(2.6%)随后与专门的姑息治疗团队或其他支持性专科团队取得联系,458 名 SC+CPs(28.8%)和 605 名 SC-CPs(38.1%)继续接受标准肿瘤学治疗。在反馈轮次中,最常提到的是资源(人员和 IT)和沟通方面的不足。

结论

OC 中对晚期 CPs 进行常规 SC 是可行的,但工作量相当大。在 42.2%的 CPs 中,SC 被归类为阳性,这表明需要进一步诊断或专业判断。SC 需要人员和 IT 资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/d198d8e08703/432_2023_4818_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/aa3c0f2f8ea8/432_2023_4818_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/1899649048af/432_2023_4818_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/d198d8e08703/432_2023_4818_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/aa3c0f2f8ea8/432_2023_4818_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/1899649048af/432_2023_4818_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc4/10374724/d198d8e08703/432_2023_4818_Fig3_HTML.jpg

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