Leshchenko M V
Probl Endokrinol (Mosk). 1986 Mar-Apr;32(2):67-9.
The corticosterone effect on the cyanide-sensitive (mitochondrial) respiration of liver slices of intact and adrenalectomized rats has been studied. The 10(-5) M hormone has been shown to inhibit the mitochondrial respiration of intact rat liver slices. A similar effect is observed in adrenalectomized rats after a short-term stimulation. A stimulating effect of the 10(-8) M steroid on the mitochondrial liver slices respiration is observed in adrenalectomized rats only. Both stimulating and inhibiting effects are recorded 5 min after incubation of the slices with the hormone. It has been concluded that corticosterone can produce a direct effect on the liver cell mitochondrial respiration. It has been assumed that mitochodrial respiration stimulation by a physiological level of the steroid can be important for cell preparation for hormone nucleic effect realization.
研究了皮质酮对完整大鼠和肾上腺切除大鼠肝脏切片氰化物敏感性（线粒体）呼吸的影响。已证明10^(-5)M的该激素可抑制完整大鼠肝脏切片的线粒体呼吸。在短期刺激后，肾上腺切除大鼠中观察到类似的效应。仅在肾上腺切除大鼠中观察到10^(-8)M类固醇对线粒体肝脏切片呼吸的刺激作用。在切片与激素孵育5分钟后记录到刺激和抑制作用。得出的结论是，皮质酮可对肝细胞线粒体呼吸产生直接影响。据推测，类固醇的生理水平对线粒体呼吸的刺激作用对于细胞为实现激素核酸效应做准备可能很重要。
