Departments of Obstetrics and Gynecology, Oncology, Biochemistry, and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Departments of Obstetrics and Gynecology, Oncology, Biochemistry, and Microbiology and Immunology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Trends Immunol. 2023 Jun;44(6):408-423. doi: 10.1016/j.it.2023.04.003. Epub 2023 May 3.
An increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in the context of type 2 immunity and allergic inflammation; however, growing evidence shows that IgG, IgA, and IgD also shape specific aspects of basophil functions relevant to many human diseases. We discuss recent mechanistic advances underpinning antibody-mediated basophil responses and propose strategies for the treatment of basophil-associated disorders.
越来越多的人类疾病，包括过敏、感染、炎症和癌症，都涉及到嗜碱性粒细胞的作用。嗜碱性粒细胞传统上被认为是循环中最罕见的白细胞，但最近它们已成为全身性和组织特异性免疫反应中的重要参与者。它们的功能受免疫球蛋白（Igs）的调节，这使嗜碱性粒细胞能够整合多种适应性和先天免疫信号。IgE 已被证实可调节 2 型免疫和过敏炎症背景下的嗜碱性粒细胞反应；然而，越来越多的证据表明，IgG、IgA 和 IgD 也塑造了与许多人类疾病相关的嗜碱性粒细胞功能的特定方面。我们讨论了抗体介导的嗜碱性粒细胞反应的最新机制进展，并提出了治疗与嗜碱性粒细胞相关疾病的策略。
