Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Department of Nuclear Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui, China.
Eur J Nucl Med Mol Imaging. 2023 Aug;50(10):3107-3115. doi: 10.1007/s00259-023-06251-y. Epub 2023 May 6.
Our study was to investigate the correlation between F-FDG uptake in HCC and tumor PD-L1 expression in HCC, and assess the value of F-FDG PET/CT imaging for predicting PD-L1 expression in HCC.
A total of 102 patients with confirmed HCC were included in this retrospective study. The PD-L1 expression and immune cell infiltrating of tumors were determined through immunohistochemistry staining. The SUVmax of HCC lesions were assessed using F-FDG PET/CT. The correlation between PD-L1 expression and the clinicopathological were evaluated by the Cox proportional hazards model and the Kaplan-Meier survival analysis.
The SUVmax of HCC primary tumors was higher in patients with poorly differentiated HCC, large tumor size, portal vein tumor thrombus, lymph node and distant metastases, and death. The SUVmax of HCC are correlated with the PD-L1 expression and the number of cytotoxic T cells and M2 macrophage infiltration. PD-L1 expression was significantly correlated with tumor SUVmax, tumor differentiation, tumor size, portal vein tumor thrombosis, and patient survival status and infiltrating M2 macrophages. Further, our results confirmed that SUVmax, portal vein tumor thrombosis, and the number of infiltrating M2 macrophages were closely related to PD-L1 expression and were independent risk factors by multivariate analysis. The combined assessment of SUVmax values and the presence of portal vein tumor thrombosis by F-FDG PET/CT imaging can help determine PD-L1 expression in HCC.
FDG uptake in HCC was positively correlated with the PD-L1 expression and the number of cytotoxic T cells and M2 macrophage infiltration. The combined use of SUVmax and portal vein tumor thrombosis by PET/CT imaging assess the PD-L1 expression better in HCC. These findings also provide a basis for clinical studies to assess the immune status of tumors by PET/CT.
本研究旨在探讨 HCC 中 F-FDG 摄取与肿瘤 PD-L1 表达的相关性，并评估 F-FDG PET/CT 成像预测 HCC 中 PD-L1 表达的价值。
本回顾性研究共纳入 102 例经证实的 HCC 患者。通过免疫组织化学染色测定肿瘤的 PD-L1 表达和免疫细胞浸润。使用 F-FDG PET/CT 评估 HCC 病变的 SUVmax。通过 Cox 比例风险模型和 Kaplan-Meier 生存分析评估 PD-L1 表达与临床病理特征的相关性。
HCC 原发肿瘤的 SUVmax 在低分化 HCC、肿瘤体积大、门静脉癌栓、淋巴结和远处转移以及死亡的患者中较高。HCC 的 SUVmax 与 PD-L1 表达以及细胞毒性 T 细胞和 M2 巨噬细胞浸润的数量相关。PD-L1 表达与肿瘤 SUVmax、肿瘤分化、肿瘤大小、门静脉癌栓以及患者生存状态和浸润的 M2 巨噬细胞显著相关。此外，我们的结果证实 SUVmax、门静脉癌栓和浸润的 M2 巨噬细胞数量与 PD-L1 表达密切相关，是多变量分析的独立危险因素。F-FDG PET/CT 成像评估 SUVmax 值和门静脉癌栓的存在有助于确定 HCC 中的 PD-L1 表达。
HCC 中的 FDG 摄取与 PD-L1 表达以及细胞毒性 T 细胞和 M2 巨噬细胞浸润的数量呈正相关。PET/CT 成像联合使用 SUVmax 和门静脉癌栓可更好地评估 HCC 中的 PD-L1 表达。这些发现也为通过 PET/CT 评估肿瘤免疫状态的临床研究提供了依据。
