Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.
School of Life Science and Health Engineering, Hebei University of Technology, Tianjin, 300401, China.
Small Methods. 2023 Jul;7(7):e2201618. doi: 10.1002/smtd.202201618. Epub 2023 May 6.
Infectious diseases caused by various bacteria pose a serious threat to human health, and the emergence of drug-resistant bacteria has forced humans to develop new and effective antimicrobial agents and strategies. Herein, a metal-organic framework-derived Bi S /FeS heterojunction (BFS) is synthesized, and the materials-microorganism interface is further constructed. Through interfacial electron transfer, electrons are transferred from the bacteria to the BFS surface, disrupting the balance of the bacterial electron transport chain and inhibiting the metabolic activity of the bacteria. Moreover, BFS has enzyme-like (oxidase and peroxidase) properties and can produce a large amount of reactive oxygen species to kill additional bacteria. In vitro antibacterial results show that the antibacterial efficiency of BFS against both Staphylococcus aureus and Escherichia coli reaches more than 99.9% after 4 h of co-culture under dark conditions. Meanwhile, in vivo experiments show that BFS can effectively kill bacteria and promote wound healing. This work shows that BFS could be a novel, effective nanomaterial for the treatment of bacterial infections by constructing the materials-microorganism interface.
各种细菌引起的传染病对人类健康构成严重威胁，而耐药菌的出现迫使人类开发新的、有效的抗菌药物和策略。在此，合成了一种金属-有机骨架衍生的 Bi S/FeS 异质结（BFS），并进一步构建了材料-微生物界面。通过界面电子转移，电子从细菌转移到 BFS 表面，破坏细菌电子传递链的平衡并抑制细菌的代谢活性。此外，BFS 具有酶样（氧化酶和过氧化物酶）特性，可以产生大量的活性氧来杀死额外的细菌。体外抗菌结果表明，在黑暗条件下共培养 4 小时后，BFS 对金黄色葡萄球菌和大肠杆菌的抗菌效率均达到 99.9%以上。同时，体内实验表明 BFS 可以有效杀死细菌并促进伤口愈合。这项工作表明，通过构建材料-微生物界面，BFS 可能成为一种治疗细菌感染的新型有效纳米材料。
