Program in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Program in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Curr Opin Chem Biol. 2023 Aug;75:102313. doi: 10.1016/j.cbpa.2023.102313. Epub 2023 May 4.
Protein citrullination is a post-translational modification of arginine that controls a diverse array of cellular processes, including gene regulation, protein stability, and neutrophil extracellular trap (NET) formation. Histone citrullination promotes chromatin decondensation and NET formation, a pro-inflammatory form of cell death that is aberrantly increased in numerous immune disorders. This review will provide insights into NETosis and how this novel form of cell death contributes to inflammatory diseases, with a particular emphasis on its role in thrombosis. We will also discuss recent efforts to develop PAD-specific inhibitors.
蛋白质瓜氨酸化是精氨酸的一种翻译后修饰，它控制着多种细胞过程，包括基因调控、蛋白质稳定性和中性粒细胞胞外诱捕网（NET）的形成。组蛋白瓜氨酸化促进染色质解凝聚和 NET 的形成，这是一种促炎形式的细胞死亡，在许多免疫紊乱中异常增加。本综述将提供有关 NETosis 的见解，以及这种新的细胞死亡形式如何导致炎症性疾病，特别强调其在血栓形成中的作用。我们还将讨论最近开发 PAD 特异性抑制剂的努力。
