Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Clinical Big Data Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Int J Cardiol. 2023 Aug 1;384:100-106. doi: 10.1016/j.ijcard.2023.04.060. Epub 2023 May 4.
The aim of this study was to estimate the burden of rheumatic heart disease (RHD) and its trends in different countries, regions, genders and age groups globally.
Data were obtained from the Global Burden of Disease 2019 study. Age-standardized rates (ASRs) and the estimated annual percentage changes (EAPCs) in the ASRs were used to describe the burden of disease and its trends. Pearson's correlation was used to evaluate the correlation between sociodemographic index (SDI) values and the observed trends.
In 2019, the ASRs of the incidence, prevalence, mortality and disability-adjusted life years (DALYs) of RHD were 37.39/10 (95%UI, 28.59/10 to 46.74/10), 513.68/10 (95%UI, 405.01/10 to 636.25/10), 3.85/10 (95%UI, 4.29/10 to 3.29/10) and 132.88/10 (95%UI, 115.02/10 to 150.34/10), respectively. From 1990 to 2019, the incidence and prevalence of RHD showed upward trends and the mortality and DALYs showed downward trends. Countries or regions in Africa, South America and South Asia had a greater burden of RHD. The burden of RHD was greater in women, where as men showed more obvious increasing trends in the incidence and prevalence. The incidence of RHD was highest in adolescents, and the prevalence was highest in young and middle-aged. The mortality and DALYs rate associated with RHD increased with age. The EAPCs in the ASRs were negatively correlated with the SDI value.
Although the ASRs of mortality and DALYs attributable to RHD are decreasing globally, RHD remains an important public health problem that needs to be addressed urgently, especially in certain low- and middle-income countries and regions.
本研究旨在估算全球不同国家/地区、性别和年龄组的风湿性心脏病（RHD）负担及其趋势。
数据来自 2019 年全球疾病负担研究。采用年龄标准化率（ASR）和估计的年变化百分比（EAPC）来描述疾病负担及其趋势。采用 Pearson 相关系数评估社会人口指数（SDI）值与观察到的趋势之间的相关性。
2019 年，RHD 的发病率、患病率、死亡率和伤残调整生命年（DALYs）的 ASR 分别为 37.39/10（95%UI，28.59/10 至 46.74/10）、513.68/10（95%UI，405.01/10 至 636.25/10）、3.85/10（95%UI，4.29/10 至 3.29/10）和 132.88/10（95%UI，115.02/10 至 150.34/10）。1990 年至 2019 年期间，RHD 的发病率和患病率呈上升趋势，死亡率和 DALYs 呈下降趋势。非洲、南美洲和南亚的国家或地区 RHD 负担较重。RHD 的负担在女性中更大，而男性的发病率和患病率呈明显上升趋势。RHD 的发病率在青少年中最高，患病率在青年和中年中最高。与 RHD 相关的死亡率和 DALYs 率随年龄增长而增加。ASR 的 EAPC 与 SDI 值呈负相关。
尽管全球 RHD 死亡率和 DALYs 的 ASR 呈下降趋势，但 RHD 仍然是一个亟待解决的重要公共卫生问题，特别是在某些中低收入国家和地区。
