Chen Mingxing, Li Jiangxi, Su Wei, Huang Junming, Yang Chuanzhen, Li Rui, Chen Gang
Medical Research Public Service Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Beijing, China.
School of Life Science, Jiangxi Science &Technology Normal University, Nanchang, China.
Cancer Med. 2025 May;14(9):e70957. doi: 10.1002/cam4.70957.
The aim of this study was to estimate the global burden of lip and oral cavity cancer (LOC) and its trends in different genders, age groups, regions, and countries globally.
Data were sourced from the Global Burden of Disease 2021 study.
During the 32-year period, a 92.92% and 113.94% increase was estimated in the absolute counts of LOC deaths and disability-adjusted life years (DALYs), respectively. Throughout the 32-year period, males exhibited higher age-standardized rates (ASRs) of incidence (ASIRs), prevalence (ASPRs), mortality (ASMRs), and DALYs (ASDRs) related to LOC. The age group of 60-64 years consistently recorded the highest numbers of new and prevalent cases across the years 1990, 2019, and 2021. In 2019 and 2021, the highest ASMR and ASDR were observed in individuals aged 95 years and older. Regions with low-middle and low socio-demographic index (SDI) consistently showed higher ASMRs and ASDRs associated with LOC from 1990 to 2021. Eastern Europe, South, North, and Southeast Asia exhibited a concentration of countries with higher ASIRs, ASPRs, ASMRs, and ASDRs in 2021. South Asia maintained high levels of ASIRs, ASPRs, ASMRs, and ASDRs in 2021. In 2021, Palau recorded the highest ASIR, ASPR, ASMR, and ASDR, followed by Pakistan. Projections indicate that ASIR, ASPR, ASMR, and ASDR are expected to increase by 7.40%, 10.10%, 2.85%, and 4.60%, respectively, from 2021 to 2040.
LOC remains a critical public health concern that requires immediate attention, particularly among certain demographics such as males, aged 60-64 or 95 and older, as well as in low- and middle-SDI regions, particularly Eastern Europe, South Asia (notably Pakistan), North Asia, and Southeast Asia.
本研究的目的是估计全球唇癌和口腔癌（LOC）的负担及其在全球不同性别、年龄组、地区和国家的趋势。
数据来源于《2021年全球疾病负担研究》。
在这32年期间，估计LOC死亡绝对数和伤残调整生命年（DALY）分别增加了92.92%和113.94%。在整个32年期间，男性在与LOC相关的发病率（年龄标准化发病率，ASIR）、患病率（年龄标准化患病率，ASPR）、死亡率（年龄标准化死亡率，ASMR）和DALY（年龄标准化DALY率，ASDR）方面表现出更高的年龄标准化率。在1990年、2019年和2021年，60 - 64岁年龄组的新发病例和现患病例数一直最高。在2019年和2021年，95岁及以上人群的ASMR和ASDR最高。社会人口指数（SDI）处于中低和低水平的地区在1990年至2021年期间与LOC相关的ASMR和ASDR一直较高。2021年，东欧、南亚、北亚和东南亚出现了ASIR、ASPR、ASMR和ASDR较高的国家集中情况。2021年，南亚的ASIR、ASPR、ASMR和ASDR维持在较高水平。2021年，帕劳的ASIR、ASPR、ASMR和ASDR最高，其次是巴基斯坦。预测表明，从2021年到2040年，ASIR、ASPR、ASMR和ASDR预计将分别增加7.40%、10.10%、2.85%和4.60%。
LOC仍然是一个关键的公共卫生问题，需要立即引起关注，特别是在某些人群中，如男性、60 - 64岁或95岁及以上的人群，以及在社会人口指数中低水平的地区，特别是东欧、南亚（特别是巴基斯坦）、北亚和东南亚。
