Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
J Cardiol. 2023 Oct;82(4):274-278. doi: 10.1016/j.jjcc.2023.04.022. Epub 2023 May 4.
Previous studies have shown an association between hyperuricemia and microvascular diseases, but the association between uric acid and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to determine the relationship between gout and AAA.
A population-based cohort study was conducted to validate the association between gout and AAA formation. The outcome in this study was the cumulative incidence of AAA in patients with or without gout during the 14-year follow-up period.
Our analysis included 121,236 patients with gout and 121,236 propensity score-matched controls from the National Health Insurance Research Database in Taiwan. Compared to the controls, patients who had gout exhibited a significantly increased incidence of AAA development [adjusted hazard ratio (HR) = 2.465, p < 0.001]. We also found that patients who were treated with anti-gout medications had a significantly lower risk of being diagnosed with an AAA than patients who were not treated with anti-gout medications (adjusted HR = 0.489, p < 0.001).
We have provided clinical evidence that gout is associated with the development of AAA.
既往研究表明高尿酸血症与微血管疾病之间存在关联，但尿酸与腹主动脉瘤（AAA）之间的关联尚不清楚。本研究旨在确定痛风与 AAA 之间的关系。
本研究进行了一项基于人群的队列研究，以验证痛风与 AAA 形成之间的关联。本研究的结局是在 14 年的随访期间，痛风患者和无痛风患者中 AAA 的累积发生率。
我们的分析纳入了来自中国台湾全民健康保险研究数据库的 121236 例痛风患者和 121236 例倾向评分匹配对照。与对照组相比，患有痛风的患者发生 AAA 发展的风险显著增加[校正后的危险比（HR）=2.465，p<0.001]。我们还发现，与未接受痛风治疗的患者相比，接受抗痛风药物治疗的患者被诊断为 AAA 的风险显著降低（校正 HR=0.489，p<0.001）。
本研究为临床证据提供了支持，即痛风与 AAA 的发生发展相关。
