Lin Jou-Yu, Tung Che-Se, Wang Jen-Chun, Chien Wu-Chien, Chung Chi-Hsiang, Lin Chih-Yuan, Tsai Shih-Hung
Department of Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan.
Division of Medical Research & Education, Cheng Hsin General Hospital, Taipei 11220, Taiwan.
Int J Environ Res Public Health. 2021 Apr 20;18(8):4389. doi: 10.3390/ijerph18084389.
Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.
先前的研究表明，偏头痛患者中已知与心血管疾病相关的危险因素患病率更高。偏头痛与腹主动脉瘤（AAA）之间也存在共同的流行病学和分子机制。我们推测偏头痛患者患AAA的风险可能会增加。为了验证这一假设，我们使用了国民健康保险研究数据库（NHIRD）来评估偏头痛与AAA之间是否存在关联。这项基于全国人群的回顾性队列研究的数据来自台湾的NHIRD。评估的研究结果是偏头痛患者在15年随访期内AAA的累积发病率。在NHIRD的1,936,512名患者中，有53,668名（2.77%）患者被确诊患有偏头痛。与无偏头痛的患者相比，偏头痛患者在索引日期后5年发生AAA的累积风险显著更高，为3.558。在15年随访期结束时，偏头痛患者中AAA的发病率（0.98%）显著高于无偏头痛的患者（0.24%）。我们揭示了偏头痛的发生与AAA之间的关联。
