Department of Psychiatry, Center for Depression Research and Clinical Care, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.
Department of Psychiatry, Center for Depression Research and Clinical Care, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA; O'Donnell Brain Institute, UT Southwestern Medical Center, 6363 Forest Park Road, Dallas, TX 75235, USA.
Psychiatr Clin North Am. 2023 Jun;46(2):211-226. doi: 10.1016/j.psc.2023.02.001.
Major depressive disorder is characterized by depressed mood and/or anhedonia with neurovegetative symptoms and neurocognitive changes affecting an individual's functioning in multiple aspects of life. Treatment outcomes with commonly used antidepressants remain suboptimal. Treatment-resistant depression (TRD) should be considered after inadequate improvement with two or more antidepressant treatments of adequate dose and duration. TRD has been associated with increased disease burden including higher associated costs (both socially and financially) affecting both the individual and society. Additional research is needed to better understand the long-term burden of TRD to both the individual and society.
重性抑郁障碍的特征为情绪低落和/或快感缺失，伴有神经植物性症状和神经认知改变，影响个体生活的多个方面的功能。常用抗抑郁药的治疗效果仍不理想。在充分剂量和足够疗程的两种或两种以上抗抑郁药物治疗后未见充分改善，应考虑治疗抵抗性抑郁症（TRD）。TRD 与疾病负担增加相关，包括更高的相关成本（社会和经济两方面），影响个体和社会。需要进一步研究以更好地了解 TRD 对个体和社会的长期负担。
