Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Surg Pathol Clin. 2023 Jun;16(2):197-211. doi: 10.1016/j.path.2023.01.007. Epub 2023 Feb 2.
Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 and is associated with pronounced hematopathologic findings. Peripheral blood features are heterogeneous and very often include neutrophilia, lymphopenia, myeloid left shift, abnormally segmented neutrophils, atypical lymphocytes/plasmacytoid lymphocytes, and atypical monocytes. Bone marrow biopsies and aspirates are often notable for histiocytosis and hemophagocytosis, whereas secondary lymphoid organs may exhibit lymphocyte depletion, pronounced plasmacytoid infiltrates, and hemophagocytosis. These changes are reflective of profound innate and adaptive immune dysregulation, and ongoing research efforts continue to identify clinically applicable biomarkers of disease severity and outcome.
新型冠状病毒病 2019 由严重急性呼吸综合征冠状病毒 2 引起，并伴有明显的血液病理发现。外周血特征具有异质性，非常常见的包括中性粒细胞增多、淋巴细胞减少、骨髓左移、异常分叶中性粒细胞、异型淋巴细胞/浆细胞样淋巴细胞和异型单核细胞。骨髓活检和抽吸常因组织细胞增生和噬血细胞现象而显著，而次级淋巴器官可能表现为淋巴细胞耗竭、明显的浆细胞样浸润和噬血细胞现象。这些变化反映了深刻的固有和适应性免疫失调，并且正在进行的研究工作继续鉴定疾病严重程度和预后的临床适用生物标志物。
