Dai Yi-Heng, Li Caihuan, Yuan Guilong, Mo Wenhui, Chen Jun, Huang Runzhong, Wan Zhonghe, Lin Duohua, Zhong Xiangming, Li Huanqiong, Liu Ling, Shi Jipeng
Department of Neonatal, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity &Child Healthcare Hospital), Foshan, China.
Department of Neonatal, Shunde Hospital of Southern Medical University, Foshan, China.
Front Pediatr. 2023 Jul 17;11:1192268. doi: 10.3389/fped.2023.1192268. eCollection 2023.
To investigate the clinical characteristics and outcomes of newborns infected with coronavirus disease 2019 (COVID-19) during the Omicron wave.
From December 1, 2022, to January 4, 2023, clinical data were collected from neonates with COVID-19 who were admitted to 10 hospitals in Foshan City, China. Their epidemiological histories, clinical manifestations and outcomes were analysed. The neonates were divided into symptomatic and asymptomatic groups. The test or test was used for comparisons between groups.
A total of 286 children were diagnosed, including 166 males, 120 females, 273 full-term infants and 13 premature infants. They were 5.5 (0-30) days old on average when they were admitted to the hospital. These children had contact with patients who tested positive for COVID-19 and were infected through horizontal transmission. This study included 33 asymptomatic and 253 symptomatic patients, among whom 143 were diagnosed with upper respiratory tract infections and 110 were diagnosed with pneumonia. There were no severe or critical patients. Fever (220 patients) was the most common clinical manifestation, with a duration of 1.1 (1-6) days. The next most common clinical manifestations were cough with nasal congestion or runny nose (4 patients), cough (34 patients), poor appetite (7 patients), shortness of breath (15 patients), and poor general status (1 patient). There were no significant abnormalities in routine blood tests among the neonates infected with COVID-19 except for mononucleosis. However, compared with the asymptomatic group, in the symptomatic group, the leukocyte and neutrophil granulocyte counts were significantly decreased, and the monocyte count was significantly increased. C-reactive protein (CRP) levels were significantly increased (≥10 mg/L) in 9 patients. Myocardial enzyme, liver function, kidney function and other tests showed no obvious abnormalities.
In this study, neonates infected with the Omicron variant were asymptomatic or had mild disease. Symptomatic patients had lower leucocyte and neutrophil levels than asymptomatic patients.
调查在奥密克戎毒株流行期间感染新型冠状病毒肺炎（COVID-19）的新生儿的临床特征及转归。
收集2022年12月1日至2023年1月4日期间在中国佛山市10家医院收治的COVID-19新生儿的临床资料，分析其流行病学史、临床表现及转归。将新生儿分为有症状组和无症状组，采用检验或检验进行组间比较。
共诊断出286例患儿，其中男166例，女120例，足月儿273例，早产儿13例。入院时平均年龄为5.5（0 - 30）天。这些患儿与COVID-19检测呈阳性的患者有接触，并通过水平传播感染。本研究包括33例无症状患者和253例有症状患者，其中143例诊断为上呼吸道感染，110例诊断为肺炎。无重症或危重症患者。发热（220例患者）是最常见的临床表现，持续时间为1.1（1 - 6）天。其次常见的临床表现为咳嗽伴鼻塞或流涕（4例患者）、咳嗽（34例患者）、食欲减退（7例患者）、呼吸急促（15例患者）和一般状况差（1例患者）。COVID-19感染新生儿的血常规检查除单核细胞增多外无明显异常。然而，与无症状组相比，有症状组白细胞和中性粒细胞计数显著降低，单核细胞计数显著升高。9例患者C反应蛋白（CRP）水平显著升高（≥10 mg/L）。心肌酶、肝功能、肾功能等检查无明显异常。
在本研究中，感染奥密克戎毒株的新生儿无症状或病情较轻。有症状患者的白细胞和中性粒细胞水平低于无症状患者。
