头孢菌素类药物对犬猫产多种超广谱β-内酰胺酶的肺炎克雷伯菌、奇异变形杆菌和阴沟肠杆菌的体外疗效。
In vitro efficacy of cephamycins against multiple extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae isolates from dogs and cats.
机构信息
Laboratory of Veterinary Internal Medicine, Tottori University, Tottori, Japan.
Joint Graduate School of Veterinary Sciences, Tottori University, Tottori, Japan.
出版信息
J Vet Med Sci. 2023 Jun 13;85(6):653-656. doi: 10.1292/jvms.23-0052. Epub 2023 May 8.
Abstract
The susceptibility of 218 extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae isolates from companion animals to three cephamycins (cefmetazole, flomoxef, and latamoxef) was investigated. Phenotypic testing found 8 of 120 Klebsiella pneumoniae (KP) and 15 of 69 Enterobacter cloacae (EC) isolates were ESBL and AmpC β-lactamase (ABL) co-producers. Isolates of KP, Proteus mirabilis, and EC that only produced ESBL exhibited susceptibility rates to cefmetazole (95.5%, 82.7%, and 9.3%), flomoxef (99.1%, 96.6%, and 74.0%), and latamoxef (99.1%, 100%, and 100%), respectively. Notably, isolates of KP and EC co-producing ESBL and ABL had significantly lower susceptibility rates to the studied drugs when compared with only ESBL producers. This implies that the in vitro activity of cephamycins against ESBL-producing bacteria can differ depending on ABL production and bacterial species.
摘要
本研究调查了 218 株来自伴侣动物的产超广谱β-内酰胺酶（ESBL）肠杆菌科细菌对三种头孢菌素（头孢美唑、头孢呋辛和拉氧头孢）的敏感性。表型检测发现，120 株肺炎克雷伯菌（KP）中有 8 株和 69 株阴沟肠杆菌（EC）中有 15 株是 ESBL 和 AmpCβ-内酰胺酶（ABL）的共生产者。仅产 ESBL 的 KP、奇异变形杆菌和 EC 分离株对头孢美唑（95.5%、82.7%和 9.3%）、头孢呋辛（99.1%、96.6%和 74.0%）和拉氧头孢（99.1%、100%和 100%）的敏感性率较高。值得注意的是，与仅产 ESBL 的分离株相比，同时产 ESBL 和 ABL 的 KP 和 EC 分离株对研究药物的敏感性显著降低。这表明头孢菌素对产 ESBL 细菌的体外活性可能因 ABL 产生和细菌种类而异。
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