Laboratory of Veterinary Internal Medicine, Tottori University, Tottori, Japan.
Joint Graduate School of Veterinary Sciences, Tottori University, Tottori, Japan.
J Vet Med Sci. 2023 Jun 13;85(6):653-656. doi: 10.1292/jvms.23-0052. Epub 2023 May 8.
The susceptibility of 218 extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae isolates from companion animals to three cephamycins (cefmetazole, flomoxef, and latamoxef) was investigated. Phenotypic testing found 8 of 120 Klebsiella pneumoniae (KP) and 15 of 69 Enterobacter cloacae (EC) isolates were ESBL and AmpC β-lactamase (ABL) co-producers. Isolates of KP, Proteus mirabilis, and EC that only produced ESBL exhibited susceptibility rates to cefmetazole (95.5%, 82.7%, and 9.3%), flomoxef (99.1%, 96.6%, and 74.0%), and latamoxef (99.1%, 100%, and 100%), respectively. Notably, isolates of KP and EC co-producing ESBL and ABL had significantly lower susceptibility rates to the studied drugs when compared with only ESBL producers. This implies that the in vitro activity of cephamycins against ESBL-producing bacteria can differ depending on ABL production and bacterial species.
本研究调查了 218 株来自伴侣动物的产超广谱β-内酰胺酶（ESBL）肠杆菌科细菌对三种头孢菌素（头孢美唑、头孢呋辛和拉氧头孢）的敏感性。表型检测发现，120 株肺炎克雷伯菌（KP）中有 8 株和 69 株阴沟肠杆菌（EC）中有 15 株是 ESBL 和 AmpCβ-内酰胺酶（ABL）的共生产者。仅产 ESBL 的 KP、奇异变形杆菌和 EC 分离株对头孢美唑（95.5%、82.7%和 9.3%）、头孢呋辛（99.1%、96.6%和 74.0%）和拉氧头孢（99.1%、100%和 100%）的敏感性率较高。值得注意的是，与仅产 ESBL 的分离株相比，同时产 ESBL 和 ABL 的 KP 和 EC 分离株对研究药物的敏感性显著降低。这表明头孢菌素对产 ESBL 细菌的体外活性可能因 ABL 产生和细菌种类而异。
