Agarwal Akanksha, Mendiratta Vibhu
Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India.
Indian J Dermatol. 2023 Jan-Feb;68(1):121. doi: 10.4103/ijd.ijd_461_22.
Female pattern hair loss (FPHL) affects a significant proportion of population and poses a major therapeutic challenge.
To compare the efficacy and safety profile of combination of topical minoxidil 2% plus platelet rich plasma (PRP) (group 1) and topical minoxidil 2% solution alone (group 2) in women having FPHL.
26 females with FPHL were randomised into two treatment groups. They were evaluated for increase in hair density, reduction in hair pull test (HPT), patient satisfaction score (PSS) and side effects.
Mean change of 34.92 ± 8.39 hairs/cm in group 1 ( < 0.001) and 31.21 ± 8.30 hair/cm in group 2 ( < 0.001) was seen. 16.7% and 28.6% patients in Group 1 and 2, respectively, had PSS of highly satisfied. The reduction in HPT was significant with = 0.0123 (group 1) and = 0.0128 (group 2). There was no statistically significant difference between the two groups. No major side effects were reported.
Minoxidil-PRP combination therapy is an effective modality for FPHL but is not superior to topical 2% minoxidil therapy alone. PRP is a promising option in patients with minoxidil related compliance issues.
女性型脱发（FPHL）影响着相当一部分人群，构成了重大的治疗挑战。
比较2%外用米诺地尔联合富血小板血浆（PRP）（第1组）和单独使用2%外用米诺地尔溶液（第2组）对患有FPHL女性的疗效和安全性。
26名患有FPHL的女性被随机分为两个治疗组。对她们进行了头发密度增加、拔发试验（HPT）降低、患者满意度评分（PSS）和副作用方面的评估。
第1组平均变化为34.92±8.39根头发/平方厘米（P<0.001），第2组为31.21±8.30根头发/平方厘米（P<0.001）。第1组和第2组分别有16.7%和28.6%的患者对PSS高度满意。HPT降低具有显著性，第1组P = 0.0123，第2组P = 0.0128。两组之间无统计学显著差异。未报告重大副作用。
米诺地尔 - PRP联合疗法是治疗FPHL的有效方式，但并不优于单独使用2%外用米诺地尔疗法。对于有米诺地尔相关依从性问题的患者，PRP是一个有前景的选择。
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