Puig Carlos J, Reese Robert, Peters Michelle
*Physicians Hair Restoration Center, Houston, Texas; †Reese Hair Restoration, Edina, Minnesota; ‡Research & Applied Statistics, University of Houston-Clear Lake School of Education, Houston, Texas.
Dermatol Surg. 2016 Nov;42(11):1243-1247. doi: 10.1097/DSS.0000000000000883.
Platelet-rich plasma (PRP) has been suggested as a therapeutic intervention for female androgenetic alopecia.
To perform a pilot study on the effect of PRP scalp injections in women with female androgenetic alopecia.
This double-blind, multicenter, placebo-controlled study compared the effect of PRP with that of saline placebo as scalp injection. The endpoints were hair count and hair mass index (HMI), along with patient-opinion survey responses. Platelet-rich plasma was manufactured from patients' blood using the Angel PRP system.
Hair mass index or hair count did not statistically significantly differ between the study and placebo groups. However, 13.3% of the treatment subjects (vs 0% of the placebo subjects) experienced substantial improvement in hair loss, rate of hair loss, hair thickness, and ease of managing/styling hair, and 26.7% (vs 18.2% of the placebo group) reported that their hair felt coarser or heavier after the treatment.
Platelet-rich plasma failed to demonstrate any statistically significant improvement in HMI or hair count in women with congenital female pattern hair loss. The patient survey results suggest a therapeutic advantage of PRP as perceived by patients but not according to hair count or HMI.
富血小板血浆（PRP）已被提议作为女性雄激素性脱发的一种治疗干预措施。
对PRP头皮注射治疗女性雄激素性脱发的效果进行一项初步研究。
这项双盲、多中心、安慰剂对照研究比较了PRP与生理盐水安慰剂头皮注射的效果。终点指标为头发数量和头发质量指数（HMI），以及患者意见调查的反馈。使用Angel PRP系统从患者血液中制备富血小板血浆。
研究组和安慰剂组之间的头发质量指数或头发数量在统计学上无显著差异。然而，13.3%的治疗受试者（安慰剂组为0%）在脱发、脱发率、头发厚度以及头发打理/造型的便利性方面有显著改善，并且26.7%的治疗受试者（安慰剂组为18.2%）报告治疗后头发感觉更粗或更厚重。
富血小板血浆未能在先天性女性型脱发女性的HMI或头发数量方面显示出任何统计学上的显著改善。患者调查结果表明，患者认为PRP具有治疗优势，但根据头发数量或HMI并非如此。
