Alghamdi Ali Hendi, Ahmed Aimun A E, Bashir Mahadi, Abdalgadir Haidar, Khalid Asaad, Gul Sheraz
Surgery Department, Faculty of Medicine, Al Baha University, Al Baha, Saudi Arabia.
Pharmacology Department, Faculty of Medicine, Al Baha University, Al Baha, Saudi Arabia.
Heliyon. 2023 Apr 11;9(4):e15340. doi: 10.1016/j.heliyon.2023.e15340. eCollection 2023 Apr.
This study aimed to assess and compile the available research articles about medicinal plants used for ocular diseases.
A total of 2949 articles were retrieved, 35 full-text articles were assessed for eligibility, and seven studies (4 observational and three experimental) with low to moderate quality were eligible and involved in the systematic review, with a total of 600 plants from 4 countries. Among the 600 plants, only 24 (4%) were used to assess the status. Both the fixed and random models of the studies showed that the included studies tended to predict the results for the observational studies (OR = 0.062, CI = 0.043-0.090 OR = 0.039, CI = 0.012-0.122) for different plants used for ocular diseases. High heterogeneity (estimated as I = 87.078, Tau = 1.161 and Q-value = 23.217 with a -value of 0.000), while for experimental studies (I = 94.928, Tau = 23.211 and Q-value = 39.434 with a -value of 0.000) and publication bias were reported.
Few articles representing approximately 600 plants of low to moderate quality reported using medicinal plants for ocular diseases. The meta-analysis confirmed the systematic review findings regarding the plants' traditional use with high heterogeneity and publication bias. A considerable gap was proven in the use of medicinal plants in ocular diseases requiring intensive research.
本研究旨在评估和汇编有关用于眼部疾病的药用植物的现有研究文章。
共检索到2949篇文章，评估了35篇全文文章的 eligibility，7项质量低至中等的研究（4项观察性研究和3项实验性研究）符合要求并纳入系统评价，涉及来自4个国家的600种植物。在这600种植物中，仅24种（4%）被用于评估其 status。研究的固定模型和随机模型均表明，纳入的研究倾向于预测用于眼部疾病的不同植物的观察性研究结果（OR = 0.062，CI = 0.043 - 0.090；OR = 0.039，CI = 0.012 - 0.122）。报告了高异质性（估计I = 87.078，Tau = 1.161，Q值 = 23.217，P值 = 0.000），而实验性研究（I = 94.928，Tau = 23.211，Q值 = 39.434，P值 = 0.000）和发表偏倚也存在。
很少有文章报道使用质量低至中等的约600种药用植物治疗眼部疾病。荟萃分析证实了系统评价的结果，即这些植物的传统用途存在高异质性和发表偏倚。在眼部疾病中使用药用植物方面存在很大差距，需要深入研究。
Zotero 插件
