一种用于胶质瘤预后的新型25个铁死亡相关基因特征
A novel 25-ferroptosis-related gene signature for the prognosis of gliomas.
作者信息
Peng Xiaojiang, Liu Chun, Li Jing, Bao Zeqing, Huang Tao, Zeng Lingfeng, He Qixiong, Xue Daojin
机构信息
Zhaoqing Medical College, Zhaoqing, China.
Department of Neurosurgery, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huaian, China.
出版信息
Front Oncol. 2023 Apr 20;13:1128278. doi: 10.3389/fonc.2023.1128278. eCollection 2023.
BACKGROUND
Ferroptosis is closely associated with cancer and is of great importance in the immune evasion of cancer. However, the relationship between ferroptosis and glioma is unclear.
METHODS
We downloaded the expression profiles and clinical data of glioma from the GlioVis database and obtained the expression profiles of ferroptosis genes. A ferroptosis-related gene signature was developed for the prognosis of gliomas.
RESULTS
We screened out prognostic ferroptosis genes, named ferroptosis-related genes, by the Cox regression method. Based on these genes, we used unsupervised clustering to obtain two different clusters; the principal component analysis algorithm was applied to determine the gene score of each patient, and then all the patients were classified into two subgroups. Results showed that there exist obvious differences in survival between different clusters and different gene score subgroups. The prognostic model constructed by the 25 ferroptosis-related genes was then evaluated to predict the clinicopathological features of immune activity in gliomas.
CONCLUSION
The ferroptosis-related genes play an important role in the malignant process of gliomas, potentially contributing to the development of prognostic stratification and treatment strategies.
背景
铁死亡与癌症密切相关，在癌症免疫逃逸中具有重要意义。然而，铁死亡与胶质瘤之间的关系尚不清楚。
方法
我们从GlioVis数据库下载了胶质瘤的表达谱和临床数据，并获得了铁死亡相关基因的表达谱。构建了一个与铁死亡相关的基因特征用于预测胶质瘤的预后。
结果
我们通过Cox回归方法筛选出预后性铁死亡基因，即铁死亡相关基因。基于这些基因，我们采用无监督聚类获得两个不同的簇；应用主成分分析算法确定每个患者的基因评分，然后将所有患者分为两个亚组。结果表明，不同簇和不同基因评分亚组之间的生存率存在明显差异。随后对由25个铁死亡相关基因构建的预后模型进行评估，以预测胶质瘤免疫活性的临床病理特征。
结论
铁死亡相关基因在胶质瘤的恶性进展中起重要作用，可能有助于预后分层和治疗策略的制定。
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