Faculty of Medicine, Yeditepe University, Istanbul, Türkiye.
Department of Histology and Embryology, Yeditepe University Faculty of Medicine, Istanbul, Türkiye.
Front Endocrinol (Lausanne). 2023 Apr 20;14:1150017. doi: 10.3389/fendo.2023.1150017. eCollection 2023.
Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis. Together with cell adhesion molecules and cytoskeletal elements, intercellular junctions orchestrate mechanotransduction, morphokinetics and signaling networks during the development of early embryos. This review focuses on the structure, organization, function and expressional pattern of the cell-cell junction complexes during early embryonic development. Understanding the importance of dynamic junction formation and maturation processes will shed light on the molecular mechanism behind developmental abnormalities of early embryos during the preimplantation period.
细胞连接形成了细胞间的强连接，并在胚胎植入前的胚胎发育过程中介导细胞间的通讯，因此对于细胞完整性、极性、细胞命运特化和形态发生至关重要。细胞连接与细胞黏附分子和细胞骨架成分一起，在早期胚胎的发育过程中协调机械转导、形态发生动力学和信号网络。本综述重点介绍了早期胚胎发育过程中细胞连接复合体的结构、组织、功能和表达模式。了解动态连接形成和成熟过程的重要性将揭示植入前胚胎发育异常的分子机制。
