卵胞浆内单精子注射后裸卵的命运：一例病例报告及文献复习
The Fate of Zona free Oocyte Following Intracytoplasmic Sperm Injection: A Case Report and Review of Literature.
作者信息
Faizah Zakiyatul, Laurus Geraldo, Lie Vellyana, Hendarto Hendy
机构信息
Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Biomedical Science, Universitas Airlangga, Surabaya, Indonesia.
出版信息
J Hum Reprod Sci. 2025 Jan-Mar;18(1):48-53. doi: 10.4103/jhrs.jhrs_174_24. Epub 2025 Mar 29.
The zona pellucida (ZP) is essential in reproductive biology, covering sperm selection, species-specific fertilisation, inhibition of polyspermy and stability of blastomeres in embryos. This case report highlights the developmental potential of a zona-free oocyte (ZFO). A 44-year-old woman produced a single oocyte, where detachment of the ZP occurred during the denudation process, leaving a ZFO. This oocyte underwent intracytoplasmic sperm injection (ICSI) and subsequent culture, developing into a four-cell embryo on the 3 day. Despite embryo transfer, no pregnancy was achieved 14 days post-transfer. This case underlines the potential for cell development in ZFOs while emphasising the challenges of achieving successful implantation.
透明带（ZP）在生殖生物学中至关重要，涵盖精子选择、物种特异性受精、多精受精抑制以及胚胎中卵裂球的稳定性。本病例报告突出了无透明带卵母细胞（ZFO）的发育潜力。一名44岁女性产生了一个单一卵母细胞，在剥除过程中透明带发生脱离，形成了一个无透明带卵母细胞。该卵母细胞接受了胞浆内单精子注射（ICSI）并随后进行培养，在第3天发育成了一个四细胞胚胎。尽管进行了胚胎移植，但移植后14天未实现妊娠。该病例强调了无透明带卵母细胞的细胞发育潜力，同时也凸显了实现成功着床的挑战。
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