Faizah Zakiyatul, Laurus Geraldo, Lie Vellyana, Hendarto Hendy
Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Biomedical Science, Universitas Airlangga, Surabaya, Indonesia.
J Hum Reprod Sci. 2025 Jan-Mar;18(1):48-53. doi: 10.4103/jhrs.jhrs_174_24. Epub 2025 Mar 29.
The zona pellucida (ZP) is essential in reproductive biology, covering sperm selection, species-specific fertilisation, inhibition of polyspermy and stability of blastomeres in embryos. This case report highlights the developmental potential of a zona-free oocyte (ZFO). A 44-year-old woman produced a single oocyte, where detachment of the ZP occurred during the denudation process, leaving a ZFO. This oocyte underwent intracytoplasmic sperm injection (ICSI) and subsequent culture, developing into a four-cell embryo on the 3 day. Despite embryo transfer, no pregnancy was achieved 14 days post-transfer. This case underlines the potential for cell development in ZFOs while emphasising the challenges of achieving successful implantation.
透明带（ZP）在生殖生物学中至关重要，涵盖精子选择、物种特异性受精、多精受精抑制以及胚胎中卵裂球的稳定性。本病例报告突出了无透明带卵母细胞（ZFO）的发育潜力。一名44岁女性产生了一个单一卵母细胞，在剥除过程中透明带发生脱离，形成了一个无透明带卵母细胞。该卵母细胞接受了胞浆内单精子注射（ICSI）并随后进行培养，在第3天发育成了一个四细胞胚胎。尽管进行了胚胎移植，但移植后14天未实现妊娠。该病例强调了无透明带卵母细胞的细胞发育潜力，同时也凸显了实现成功着床的挑战。
