Kikuta Shogo, Teratani Yui, Matsuo Katsuhisa, Kusukawa Jingo
Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, JPN.
Cureus. 2023 Apr 2;15(4):e37046. doi: 10.7759/cureus.37046. eCollection 2023 Apr.
Oral cancer is a disease primarily in older adults and extremely rare in young adults. Risk factors for oral cancer are irritants such as tobacco smoke and alcohol and chronic mechanical irritants but mechanisms involved in carcinogenesis in young adults are unclear because of less exposure to their risk factors. Herein, we report a rare case of gingival squamous cell carcinoma in a 19-year-old female patient, in whom the tumor predictably originated in the gingival sulcular epithelium. Histopathological examination of the resected tissue showed a cancer cell nest invading from the gingival sulcular epithelium without a breakdown of the basement membrane of the marginal gingival epithelium. Six years after the surgery, no recurrence or metastasis has been detected.
口腔癌主要是一种发生于老年人的疾病，在年轻人中极为罕见。口腔癌的风险因素包括烟草烟雾和酒精等刺激物以及慢性机械刺激，但由于年轻人接触这些风险因素较少，其致癌机制尚不清楚。在此，我们报告一例19岁女性患者的罕见牙龈鳞状细胞癌病例，该肿瘤可推测起源于牙龈沟上皮。对切除组织的组织病理学检查显示，癌细胞巢从牙龈沟上皮侵入，而边缘牙龈上皮的基底膜未被破坏。手术后六年，未检测到复发或转移。
