Hernandez Oscar L, Suarez Zoilo K, Nagi Talwinder, Vallejo Charles, Ferris Allison
Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus. 2023 Apr 3;15(4):e37062. doi: 10.7759/cureus.37062. eCollection 2023 Apr.
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic transmural inflammation of any portion of the gastrointestinal tract. The etiology of CD remains unknown although genetic, immunological, and acquired factors have been recognized as contributing to its development. Alterations of intestinal microbiota, including (), are theorized to alter humoral immunity and contribute toward CD flare pathogenesis. As such, cases of IBD remission can be undone by alterations in the gut microbiota and subsequently confound the diagnosis of inflammatory or infectious etiologies of diarrhea. We present a case of a 73-year-old female with dormant CD for 25 years who experienced an atypical course of diarrhea found to have a CD flare in the setting of acute colitis.
克罗恩病（CD）是一种炎症性肠病（IBD），其特征为胃肠道任何部位的慢性透壁性炎症。尽管遗传、免疫和后天因素已被认为与CD的发生有关，但其病因仍不明。肠道微生物群的改变，包括（此处原文缺失内容），被认为会改变体液免疫并促成CD发作的发病机制。因此，肠道微生物群的改变可能会使IBD缓解的病例复发，进而混淆腹泻的炎症性或感染性病因的诊断。我们报告一例73岁女性，患有静止期CD 25年，经历了非典型腹泻病程，发现在急性结肠炎背景下出现了CD发作。
