Maxwell Anthony, Adzibolosu Nicholas, Hu Anna, You Yuan, Stemmer Paul M, Ruden Douglas M, Petriello Michael C, Sadagurski Marianna, Debarba Lucas K, Koshko Lisa, Ramadoss Jayanth, Nguyen Annie Thy, Richards Darby, Liao Aihua, Mor Gil, Ding Jiahui
C.S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
iScience. 2023 Feb 27;26(4):106287. doi: 10.1016/j.isci.2023.106287. eCollection 2023 Apr 21.
Maternal immune activation (MIA) by environmental challenges is linked to severe developmental complications, such as neurocognitive disorders, autism, and even fetal/maternal death. Benzene is a major toxic compound in air pollution that affects the mother as well as the fetus and has been associated with reproductive complications. Our objective was to elucidate whether benzene exposure during gestation triggers MIA and its impact on fetal development. We report that benzene exposure during pregnancy leads MIA associated with increased fetal resorptions, fetal growth, and abnormal placenta development. Furthermore, we demonstrate the existence of a sexual dimorphic response to benzene exposure in male and female placentas. The sexual dimorphic response is a consequence of inherent differences between male and female placenta. These data provide crucial information on the origins or sexual dimorphism and how exposure to environmental factors can have a differential impact on the development of male and female offspring.
环境挑战引发的母体免疫激活（MIA）与严重的发育并发症有关，如神经认知障碍、自闭症，甚至胎儿/母体死亡。苯是空气污染中的一种主要有毒化合物，会影响母亲和胎儿，并与生殖并发症有关。我们的目标是阐明孕期接触苯是否会引发MIA及其对胎儿发育的影响。我们报告称，孕期接触苯会导致MIA，伴有胎儿吸收率增加、胎儿生长和胎盘发育异常。此外，我们证明了雄性和雌性胎盘对苯暴露存在性二态反应。这种性二态反应是雄性和雌性胎盘固有差异的结果。这些数据提供了关于性二态性起源以及环境因素暴露如何对雄性和雌性后代发育产生不同影响的关键信息。
