Christenson J T, Al-Hassan H K, Shawa N J
Scand J Clin Lab Invest. 1986 Apr;46(2):137-41. doi: 10.3109/00365518609083649.
The mechanisms of pain in patients with chronic iliac vein obstruction and venous claudication is not fully understood. Ten patients with severe to moderate unilateral post-thrombotic syndrome with chronic iliac vein obstruction were studied. Subcutaneous tissue pressures and intramuscular pressures were measured using the slit-catheter technique in both legs, at rest and during exercise. The subcutaneous tissue pressure was higher, but not significantly higher, in the leg with iliac vein obstruction, +2 (-2 to +10) mmHg, than in the contralateral healthy legs, 0 (-4 to +4) mmHg in supine position at rest. During exercise in the standing position the subcutaneous tissue pressure rose significantly (p less than 0.01) in the diseased leg to 9 (+4 to +15) mmHg, while no such increase was seen in the control limb, 0 (-4 to +4) versus -1 (-5 to +4) mmHg. The intramuscular pressures were significantly higher (p less than 0.01) in the leg with iliac vein obstruction 26 (15 to 42) mmHg, than in the control leg, 11 (1 to 15) mmHg at rest in supine position as well as during exercise in standing position, 64 (35 to 82) mmHg and 26 (10 to 36) mmHg, respectively.
慢性髂静脉阻塞和静脉性跛行患者的疼痛机制尚未完全明确。对10例患有中重度单侧血栓形成后综合征伴慢性髂静脉阻塞的患者进行了研究。采用裂隙导管技术在静息和运动状态下测量双腿的皮下组织压力和肌肉内压力。在静息仰卧位时，髂静脉阻塞侧腿部的皮下组织压力为+2（-2至+10）mmHg，高于对侧健康腿部的0（-4至+4）mmHg，但差异无统计学意义。在站立位运动时，患侧腿部的皮下组织压力显著升高（p<0.01）至9（+4至+15）mmHg，而对照肢体未见此类升高，分别为0（-4至+4）mmHg和-1（-5至+4）mmHg。在静息仰卧位以及站立位运动时，髂静脉阻塞侧腿部的肌肉内压力显著高于对照侧腿部，分别为26（15至42）mmHg和11（1至15）mmHg，以及64（35至82）mmHg和26（10至36）mmHg。
