Greene M H, Pinto H A, Kant J A, Siler K, Vonderheid E C, Lamberg S I, Dalager N A
Cancer. 1982 Feb 15;49(4):737-41. doi: 10.1002/1097-0142(19820215)49:4<737::aid-cncr2820490423>3.0.co;2-r.
Of 526 consecutive patients with cutaneous T-cell lymphomas, 21 had first-degree relatives with lymphoproliferative or hematopoietic malignancies. Twenty-nine such tumors occurred in the 21 kindreds. Hodgkin's disease accounted for one-third of this total, with various leukemias (11 cases), non-Hodgkin's lymphoma (five cases), and multiple myeloma (three cases) comprising the remainder. These data suggest that genetically-determined immunoregulatory abnormalities may represent a shared pathway of oncogenesis in diverse lymphoproliferative and hematopoietic malignancies.
在526例连续性皮肤T细胞淋巴瘤患者中，21例有患淋巴增殖性或造血系统恶性肿瘤的一级亲属。在这21个家族中发生了29例此类肿瘤。霍奇金病占总数的三分之一，其余包括各种白血病（11例）、非霍奇金淋巴瘤（5例）和多发性骨髓瘤（3例）。这些数据表明，基因决定的免疫调节异常可能是多种淋巴增殖性和造血系统恶性肿瘤共同的肿瘤发生途径。
