Faculty of Dentistry, Periodontology Department, Istanbul University, Istanbul, Turkey.
Perinatology Clinic, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
J Periodontal Res. 2023 Aug;58(4):745-754. doi: 10.1111/jre.13132. Epub 2023 May 8.
To compare oxidative stress (OS) markers in the saliva, gingival crevicular fluid (GCF), and serum samples of pregnant women with gestational diabetes (GDM) and healthy pregnant women and to investigate the association between periodontal health/diseases and OS and GDM.
Eighty women with GDM and 80 healthy pregnant women were included in the study. Medical and clinical anamnesis was obtained from all the pregnant women included in the study, and their plaque index (PI), gingival index (GI), bleeding on probing (BoP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were performed. GCF, saliva, and serum samples were collected for the measurements of the local and systemic total antioxidant status (TAS) and total oxidant status (TOS).
Clinical periodontal parameters were found to be significantly higher in the GDM group compared to the control group. The serum and saliva TAS, TOS, and TAS/TOS values were significantly lower in the GDM group than in the control group. In the analysis of the GCF samples, the mean TAS and TAS/TOS values were significantly lower and the TOS value was significantly higher in the GDM group than in the control group. The multivariate reduced model indicated that gravidity, salivary TAS/TOS, and GCF TAS were significant independent variables in the development of GDM (p < .05).
Our results indicated that the OS of serum, saliva, and GCF samples increased in patients with GDM compared to healthy pregnant women. The role of local OS parameters in GDM may be associated with elevated clinical periodontal parameters.
比较患有妊娠期糖尿病（GDM）的孕妇与健康孕妇的唾液、龈沟液（GCF）和血清样本中的氧化应激（OS）标志物，并探讨牙周健康/疾病与 OS 和 GDM 的关系。
本研究纳入了 80 名患有 GDM 的孕妇和 80 名健康孕妇。对所有纳入研究的孕妇进行了医学和临床病史调查，并对其菌斑指数（PI）、牙龈指数（GI）、探诊出血（BoP）、探诊深度（PPD）和临床附着水平（CAL）进行了测量。收集 GCF、唾液和血清样本，以测量局部和全身总抗氧化状态（TAS）和总氧化状态（TOS）。
与对照组相比，GDM 组的临床牙周参数明显更高。GDM 组的血清和唾液 TAS、TOS 和 TAS/TOS 值明显低于对照组。在分析 GCF 样本时，GDM 组的平均 TAS 和 TAS/TOS 值明显较低，TOS 值明显较高。多元回归模型表明，妊娠次数、唾液 TAS/TOS 和 GCF TAS 是 GDM 发生的显著独立变量（p<0.05）。
我们的结果表明，与健康孕妇相比，患有 GDM 的孕妇的血清、唾液和 GCF 样本中的 OS 增加。局部 OS 参数在 GDM 中的作用可能与升高的临床牙周参数有关。
