Dursun Erhan, Akalin Ferda Alev, Genc Tolga, Cinar Nese, Erel Ozcan, Yildiz Bulent Okan
From the Department of Periodontology (ED, FAA, TG), Faculty of Dentistry; Division of Endocrinology and Metabolism (NC, BOY), Department of Internal Medicine, Faculty of Medicine, Hacettepe University; and Department of Biochemistry (OE), Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Medicine (Baltimore). 2016 Mar;95(12):e3136. doi: 10.1097/MD.0000000000003136.
Periodontal disease is a chronic inflammatory disease of the jaws and is more prevalent in obesity. Local and systemic oxidative stress may be an early link between periodontal disease and obesity. The primary aim of this study was to detect whether increased periodontal disease susceptibility in obese individuals is associated with local and systemic oxidative stress. Accordingly; we analyzed periodontal status and systemic (serum) and local (gingival crevicular fluid [GCF]) oxidative status markers in young obese women in comparison with age-matched lean women.Twenty obese and 20 lean women participated. Periodontal condition was determined by clinical periodontal indices including probing depth, clinical attachment level, gingival index, gingival bleeding index, and plaque index. Anthropometric, hormonal, and metabolic measurements were also performed. Blood and GCF sampling was performed at the same time after an overnight fasting. Serum and GCF total antioxidant capacity (TAOC), and total oxidant status (TOS) levels were determined, and oxidative stress index (OSI) was calculated.Clinical periodontal analyses showed higher gingival index and gingival bleeding index in the obese group (P = 0.001 for both) with no significant difference in probing depth, clinical attachment level, and plaque index between the obese and the lean women. Oxidant status analyses revealed lower GCF and serum TAOC, and higher GCF and serum OSI values in the obese women (P < 0.05 for all). GCF TOS was higher in the obese women (P < 0.05), whereas there was a nonsignificant trend for higher serum TOS in obese women (P = 0.074). GCF TAOC values showed a negative correlation with body mass index, whereas GCF OSI was positively correlated with fasting insulin and low-density lipoprotein-cholesterol levels (P < 0.05 for all). Clinical periodontal indices showed significant correlations with body mass index, insulin, and lipid levels, and also oxidant status markers.Our results suggest that young obese, otherwise healthy, women show findings of early periodontal disease (gingival inflammation) compared with age-matched healthy lean women, and that local/periodontal oxidative stress generated by obesity seems to be associated with periodontal disease.
牙周病是颌骨的一种慢性炎症性疾病，在肥胖人群中更为普遍。局部和全身氧化应激可能是牙周病与肥胖之间的早期联系。本研究的主要目的是检测肥胖个体中牙周病易感性增加是否与局部和全身氧化应激相关。因此，我们分析了年轻肥胖女性与年龄匹配的瘦女性的牙周状况以及全身（血清）和局部（龈沟液[GCF]）氧化状态标志物。20名肥胖女性和20名瘦女性参与了研究。通过包括探诊深度、临床附着水平、牙龈指数、牙龈出血指数和菌斑指数在内的临床牙周指数来确定牙周状况。还进行了人体测量、激素和代谢测量。在空腹过夜后同时进行血液和GCF采样。测定血清和GCF的总抗氧化能力（TAOC）以及总氧化状态（TOS）水平，并计算氧化应激指数（OSI）。临床牙周分析显示肥胖组的牙龈指数和牙龈出血指数较高（两者P = 0.001），肥胖女性和瘦女性之间的探诊深度、临床附着水平和菌斑指数无显著差异。氧化状态分析显示肥胖女性的GCF和血清TAOC较低，GCF和血清OSI值较高（所有P < 0.05）。肥胖女性的GCF TOS较高（P < 0.05），而肥胖女性血清TOS有升高的非显著趋势（P = 0.074）。GCF TAOC值与体重指数呈负相关，而GCF OSI与空腹胰岛素和低密度脂蛋白胆固醇水平呈正相关（所有P < 0.05）。临床牙周指数与体重指数、胰岛素和脂质水平以及氧化状态标志物均有显著相关性。我们的结果表明，与年龄匹配的健康瘦女性相比，年轻肥胖但其他方面健康的女性表现出早期牙周病（牙龈炎症）的迹象，并且肥胖产生的局部/牙周氧化应激似乎与牙周病有关。
