Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey.
Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.
Arch Oral Biol. 2017 Oct;82:115-120. doi: 10.1016/j.archoralbio.2017.06.009. Epub 2017 Jun 12.
Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment.
The study groups were composed of 32 T1DM patients at diagnosis, and age- and gender-matched thirty-six systemically healthy children with (G) and without (H) gingivitis. The diabetic patients who took insulin therapy (1.5 units/kg/day totally) and periodontal treatment (oral hygiene education with professional scaling) were reevaluated after 3 months. The levels of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were recorded.
GCF, salivary, and serum OSI were elevated in group T1DM compared to the other groups at baseline (p<0.05), and decreased in group T1DM at reevaluation compared to baseline (p<0.05). GCF OSI was positively correlated with periodontal clinical parameters (p<0.05). Glycated hemoglobin was positively correlated with GCF TOS (r=0.302, p=0.007), GCF OSI (r=0.346, p=0.002), salivary TOS (r=0.326, p=0.046), and serum TOS (r=0.239, p=0.044).
The instability in the oxidative status that accompanies diabetes may be considered a significant pathogenic factor of diabetes-related periodontal inflammation.
最近，人们越来越关注氧化应激在牙周病和糖尿病病理中的作用。首先，本研究旨在分析初诊 1 型糖尿病（T1DM）儿童、无牙周病和牙龈炎的健康儿童以及有牙周病和牙龈炎的健康儿童的龈沟液（GCF）、唾液和血清氧化状态。此外，还对接受糖尿病和牙周治疗后的糖尿病患者进行了重新评估。
研究组由 32 名初诊 T1DM 患者和 36 名年龄和性别匹配的无（H）或有（G）牙周病的系统健康儿童组成。接受胰岛素治疗（1.5 单位/千克/天）和牙周治疗（口腔卫生教育和专业洁治）的糖尿病患者在 3 个月后进行重新评估。记录总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）水平。
与其他组相比，T1DM 组的 GCF、唾液和血清 OSI 在基线时升高（p<0.05），在重新评估时与基线相比降低（p<0.05）。GCF OSI 与牙周临床参数呈正相关（p<0.05）。糖化血红蛋白与 GCF TOS（r=0.302，p=0.007）、GCF OSI（r=0.346，p=0.002）、唾液 TOS（r=0.326，p=0.046）和血清 TOS（r=0.239，p=0.044）呈正相关。
糖尿病伴随的氧化状态不稳定可能被认为是糖尿病相关牙周炎的一个重要发病因素。
