Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Departments of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Exp Aging Res. 2024 Jul-Sep;50(4):443-458. doi: 10.1080/0361073X.2023.2210240. Epub 2023 May 8.
The present study was conducted to investigate the effects of L. (OB) extract on learning and memory impairment in aged rats. Male rats were divided into the following experimental groups: Group 1 (control): including 2 months old rats, Group 2 (aged) including 2 years old rats, Groups 3-5 (aged-OB): including 2 years old rats received 50, 100, and 150 mg/kg OB for 8 weeks by oral gavage. Aging increased the delay to find the platform but, however, decreased the time spent in the target quadrant when tested by Morris water maze (MWM). Aging also reduced the latency to enter the dark chamber in the passive avoidance (PA) test compared to the control group. Moreover, interleukin-6 (IL-6) and malondialdehyde (MDA) levels were raised in the hippocampus and cortex of aged rats. In contrast, thiol levels and enzymatic activity of superoxide dismutase (SOD) and catalase (CAT) significantly reduced. In addition, aging significantly reduced BDNF expression. Finally, OB administration reversed the mentioned effects. The current research showed that OB administration improves learning/memory impairment induced by aging. It also found that this plant extract protects the brain tissues from oxidative damage and neuroinflammation.
本研究旨在探讨 L.（OB）提取物对老年大鼠学习和记忆障碍的影响。雄性大鼠被分为以下实验组：第 1 组（对照组）：包括 2 个月大的大鼠；第 2 组（老年组）：包括 2 岁大的大鼠；第 3-5 组（老年-OB 组）：包括 2 岁大的大鼠，通过口服灌胃给予 50、100 和 150mg/kg 的 OB，持续 8 周。衰老增加了找到平台的延迟时间，但在 Morris 水迷宫（MWM）测试中，减少了在目标象限花费的时间。与对照组相比，衰老大鼠在被动回避（PA）测试中进入暗室的潜伏期也缩短。此外，老年大鼠海马体和皮质中的白细胞介素 6（IL-6）和丙二醛（MDA）水平升高，而巯基水平以及超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的酶活性显著降低。此外，衰老还显著降低了脑源性神经营养因子（BDNF）的表达。最后，OB 给药逆转了上述作用。目前的研究表明，OB 给药可改善衰老引起的学习/记忆障碍。它还发现，这种植物提取物可保护脑组织免受氧化损伤和神经炎症的影响。
