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高危新生儿听力筛查项目中的转诊率和假阳性率。

Referral rate and false-positive rates in a hearing screening program among high-risk newborns.

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Baldingerstrasse, 35043, Marburg, Germany.

Department of Pediatric Neurology, Social Pediatrics and Epileptology, Justus-Liebig-University Giessen and University Hospital Giessen, Feulgenstr. 10-12, 35392, Giessen, Germany.

出版信息

Eur Arch Otorhinolaryngol. 2023 Oct;280(10):4455-4465. doi: 10.1007/s00405-023-07978-y. Epub 2023 May 8.

Abstract

AIM

More studies exploring referral rates and false-positive rates are needed to make hearing screening programs in newborns better and cost-effective. Our aim was to study the referral and false-positivity rates among high-risk newborns in our hearing screening program and to analyze the factors potentially associated with false-positive hearing screening test results.

METHODS

A retrospective cohort study was done among the newborns hospitalized at a university hospital from January 2009 to December 2014 that underwent hearing screening with a two-staged AABR screening protocol. Referral rates and false-positivity rates were calculated and possible risk factors for false-positivity were analyzed.

RESULTS

4512 newborns were screened for hearing loss in the neonatology department. The referral rate for the two-staged AABR-only screening was 3.8% with false-positivity being 2.9%. Our study showed that the higher the birthweight or gestational age of the newborn, the lower the odds of the hearing screening results being false-positive, and the higher the chronological age of the infant at the time of screening, the higher the odds of the results being false-positive. Our study did not show a clear association between the mode of delivery or gender and false-positivity.

CONCLUSION

Among high-risk infants, prematurity and low-birthweight increased the rate of false-positivity in the hearing screening, and the chronological age at the time of the test seems to be significantly associated with false-positivity.

摘要

目的

需要更多研究来探索转诊率和假阳性率,以使新生儿听力筛查项目更好且具有成本效益。我们的目的是研究我们的听力筛查计划中高危新生儿的转诊率和假阳性率,并分析与假阳性听力筛查测试结果相关的潜在因素。

方法

对 2009 年 1 月至 2014 年 12 月在一所大学医院住院的新生儿进行了一项回顾性队列研究,这些新生儿接受了采用两阶段 AABR 筛查方案的听力筛查。计算了转诊率和假阳性率,并分析了假阳性的可能危险因素。

结果

新生儿科共筛查了 4512 名新生儿听力损失。两阶段 AABR 筛查的转诊率为 3.8%,假阳性率为 2.9%。我们的研究表明,新生儿的出生体重或胎龄越高,听力筛查结果假阳性的可能性越低,而在筛查时婴儿的实际年龄越大,结果假阳性的可能性越高。我们的研究没有显示分娩方式或性别与假阳性之间有明确的关联。

结论

在高危婴儿中,早产和低出生体重会增加听力筛查的假阳性率,而测试时的实际年龄似乎与假阳性率显著相关。

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