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新冠病毒相关凝血病：升主动脉血栓形成

COVID-19-Associated Coagulopathy: Ascending Aortic Thrombus.

作者信息

Mesalles Maria E, Rao Shiavax J, Sagheer Usman

机构信息

Internal Medicine, MedStar Union Memorial Hospital, Baltimore, USA.

出版信息

Cureus. 2023 Mar 23;15(3):e36607. doi: 10.7759/cureus.36607. eCollection 2023 Mar.

DOI:10.7759/cureus.36607
PMID:37155447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10122614/
Abstract

The mechanism of arterial thrombosis in coronavirus disease 2019 (COVID-19) is not completely understood and is attributed to the complex interactions of endothelial injury, platelet hyperactivation, and activated pro-inflammatory cytokines. Management strategies may include a combination of surgery and anticoagulation, or anticoagulation alone. A 56-year-old woman with recent COVID-19 infection presented with chest pain and dyspnea. Chest CT angiography (CTA) and aortic magnetic resonance imaging revealed an intraluminal thrombus in the mid ascending aorta. A multidisciplinary team decided on heparin infusion. She was transitioned to apixaban and a three-month interval outpatient CTA revealed complete resolution of the aortic thrombus.

摘要

2019冠状病毒病（COVID-19）中动脉血栓形成的机制尚未完全明确，其被认为是内皮损伤、血小板过度活化和促炎细胞因子活化之间复杂相互作用的结果。治疗策略可能包括手术与抗凝联合使用，或单独使用抗凝治疗。一名近期感染COVID-19的56岁女性出现胸痛和呼吸困难。胸部CT血管造影（CTA）和主动脉磁共振成像显示升主动脉中段管腔内有血栓。一个多学科团队决定给予肝素输注。她随后改用阿哌沙班，三个月后的门诊CTA显示主动脉血栓完全消失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/4d34124e6a51/cureus-0015-00000036607-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/06623d0e0ba1/cureus-0015-00000036607-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/55acfb622535/cureus-0015-00000036607-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/70c3c5bf8f6e/cureus-0015-00000036607-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/274945709bb2/cureus-0015-00000036607-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/4d34124e6a51/cureus-0015-00000036607-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/06623d0e0ba1/cureus-0015-00000036607-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/55acfb622535/cureus-0015-00000036607-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/70c3c5bf8f6e/cureus-0015-00000036607-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/274945709bb2/cureus-0015-00000036607-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/10122614/4d34124e6a51/cureus-0015-00000036607-i05.jpg

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Aortic Thrombus in a Nonaneurysmal Ascending Aorta.升主动脉非瘤样血栓
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Coronavirus Disease 2019-Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management.新型冠状病毒病相关血栓形成和凝血障碍：病理生理学特征综述及其对抗血栓治疗管理的影响。
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