Department of Mathematics and Statistics, Bacha Khan University, Charsadda, 24461, Pakistan.
Department of Mathematics, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Sci Rep. 2023 May 8;13(1):7421. doi: 10.1038/s41598-023-34696-6.
There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly to a susceptible animal or human host by an infected person, animal, vector, or immaterial environment. Human immunodeficiency virus (HIV) infection, hepatitis A, B, and C, and measles are all examples of communicable diseases. Acquired immunodeficiency syndrome (AIDS) is a communicable disease caused by HIV infection that has become the most severe issue facing humanity. The research work in this paper is to numerically explore a mathematical model and demonstrate the dynamics of HIV/AIDS disease transmission using a continuous Galerkin-Petrov time discretization of a higher-order scheme, specifically the cGP(2)-scheme. Depict a graphical and tabular comparison between the outcomes of the mentioned scheme and those obtained through other classical schemes that exist in the literature. Further, a comparison is performed relative to the well-known fourth-order Ruge-Kutta (RK4) method with different step sizes. By contrast, the suggested approach provided more accurate results with a larger step size than RK4 with a smaller step size. After validation and confirmation of the suggested scheme and code, we implement the method to the extended model by introducing a treatment rate and show the impact of various non-linear source terms for the generation of new cells. We also determined the basic reproduction number and use the Routh-Hurwitz criterion to assess the stability of disease-free and unique endemic equilibrium states of the HIV model.
有许多由致病微生物引起的传染病,包括细菌、病毒、真菌和寄生虫,它们有可能导致致命的后果。传染病是由感染源或其毒素引起的疾病,通过感染者、动物、媒介或无形环境直接或间接传播给易感动物或人类宿主。人类免疫缺陷病毒(HIV)感染、甲型肝炎、乙型肝炎、丙型肝炎和麻疹都是传染病的例子。获得性免疫缺陷综合征(AIDS)是由 HIV 感染引起的传染病,已成为人类面临的最严重问题。本文的研究工作是使用连续 Galerkin-Petrov 时间离散化的高阶方案,即 cGP(2)-方案,对 HIV/AIDS 疾病传播的数学模型进行数值研究,并展示其动力学。描绘所提到的方案与文献中存在的其他经典方案的结果之间的图形和表格比较。此外,还与不同步长的著名四阶龙格库塔(RK4)方法进行了比较。相比之下,与较小步长的 RK4 相比,建议的方法在较大步长下提供了更准确的结果。在验证和确认建议的方案和代码后,我们通过引入治疗率将该方法应用于扩展模型,并展示各种非线性源项对新细胞产生的影响。我们还确定了基本繁殖数,并使用劳斯-胡尔维茨准则评估 HIV 模型无病和唯一地方病平衡点的稳定性。