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通过高阶伽辽金时间离散方案研究新型 HIV/AIDS 模型的传播动力学。

Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme.

机构信息

Department of Mathematics and Statistics, Bacha Khan University, Charsadda, 24461, Pakistan.

Department of Mathematics, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.

出版信息

Sci Rep. 2023 May 8;13(1):7421. doi: 10.1038/s41598-023-34696-6.

DOI:10.1038/s41598-023-34696-6
PMID:37156899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10167370/
Abstract

There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly to a susceptible animal or human host by an infected person, animal, vector, or immaterial environment. Human immunodeficiency virus (HIV) infection, hepatitis A, B, and C, and measles are all examples of communicable diseases. Acquired immunodeficiency syndrome (AIDS) is a communicable disease caused by HIV infection that has become the most severe issue facing humanity. The research work in this paper is to numerically explore a mathematical model and demonstrate the dynamics of HIV/AIDS disease transmission using a continuous Galerkin-Petrov time discretization of a higher-order scheme, specifically the cGP(2)-scheme. Depict a graphical and tabular comparison between the outcomes of the mentioned scheme and those obtained through other classical schemes that exist in the literature. Further, a comparison is performed relative to the well-known fourth-order Ruge-Kutta (RK4) method with different step sizes. By contrast, the suggested approach provided more accurate results with a larger step size than RK4 with a smaller step size. After validation and confirmation of the suggested scheme and code, we implement the method to the extended model by introducing a treatment rate and show the impact of various non-linear source terms for the generation of new cells. We also determined the basic reproduction number and use the Routh-Hurwitz criterion to assess the stability of disease-free and unique endemic equilibrium states of the HIV model.

摘要

有许多由致病微生物引起的传染病,包括细菌、病毒、真菌和寄生虫,它们有可能导致致命的后果。传染病是由感染源或其毒素引起的疾病,通过感染者、动物、媒介或无形环境直接或间接传播给易感动物或人类宿主。人类免疫缺陷病毒(HIV)感染、甲型肝炎、乙型肝炎、丙型肝炎和麻疹都是传染病的例子。获得性免疫缺陷综合征(AIDS)是由 HIV 感染引起的传染病,已成为人类面临的最严重问题。本文的研究工作是使用连续 Galerkin-Petrov 时间离散化的高阶方案,即 cGP(2)-方案,对 HIV/AIDS 疾病传播的数学模型进行数值研究,并展示其动力学。描绘所提到的方案与文献中存在的其他经典方案的结果之间的图形和表格比较。此外,还与不同步长的著名四阶龙格库塔(RK4)方法进行了比较。相比之下,与较小步长的 RK4 相比,建议的方法在较大步长下提供了更准确的结果。在验证和确认建议的方案和代码后,我们通过引入治疗率将该方法应用于扩展模型,并展示各种非线性源项对新细胞产生的影响。我们还确定了基本繁殖数,并使用劳斯-胡尔维茨准则评估 HIV 模型无病和唯一地方病平衡点的稳定性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf92/10167370/4920f61896dd/41598_2023_34696_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf92/10167370/8648226e663e/41598_2023_34696_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf92/10167370/4b327d9a7c31/41598_2023_34696_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf92/10167370/f3f2c1fbe442/41598_2023_34696_Fig11_HTML.jpg
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3
Health related quality of life of HIV/AIDS patients on highly active anti-retroviral therapy at a university referral hospital in Ethiopia.
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BMC Health Serv Res. 2017 Nov 15;17(1):737. doi: 10.1186/s12913-017-2714-1.
4
An exponential Galerkin method for solutions of HIV infection model of CD4 T-cells.指数 Galerkin 方法求解 CD4 T 细胞 HIV 感染模型的解。
Comput Biol Chem. 2017 Apr;67:205-212. doi: 10.1016/j.compbiolchem.2016.12.006. Epub 2017 Jan 18.
5
Modelling HIV/AIDS in the presence of an HIV testing and screening campaign.在 HIV 检测和筛查运动的情况下对 HIV/AIDS 进行建模。
J Theor Biol. 2011 Jul 7;280(1):167-79. doi: 10.1016/j.jtbi.2011.04.021. Epub 2011 Apr 28.
6
Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence.接受抗逆转录病毒治疗的艾滋病毒感染者的生活质量与治疗依从性有关。
AIDS Care. 2005 Jan;17(1):10-22. doi: 10.1080/09540120412331305098.
7
Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection.自我报告的症状和药物副作用会影响艾滋病毒感染者对高效抗逆转录病毒疗法的依从性。
J Acquir Immune Defic Syndr. 2001 Dec 15;28(5):445-9. doi: 10.1097/00042560-200112150-00006.
8
A delay-differential equation model of HIV infection of CD4(+) T-cells.CD4(+) T细胞HIV感染的延迟微分方程模型。
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9
Optimal control of the chemotherapy of HIV.艾滋病病毒化疗的优化控制
J Math Biol. 1997 Aug;35(7):775-92. doi: 10.1007/s002850050076.
10
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Bull Math Biol. 1996 Mar;58(2):376-90. doi: 10.1016/0092-8240(95)00345-2.