Mima Yoshihito, Ohtsuka Tsutomu, Arakawa Nobuhito, Nakazato Yoshimasa, Norimatsu Yuta
Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, JPN.
Department of Dermatology, International University of Health and Welfare Hospital, Tochigi, JPN.
Cureus. 2025 Mar 5;17(3):e80117. doi: 10.7759/cureus.80117. eCollection 2025 Mar.
Acute generalized exanthematous pustulosis (AGEP) is a severe skin inflammation characterized by the sudden onset of numerous sterile, non-follicular pustules on an erythematous and edematous background, usually associated with fever. AGEP is commonly triggered by medications such as antibiotics. However, an association between AGEP and viral infections has also been reported recently. We report a case of a 70-year-old man who developed AGEP following the intake of an over-the-counter cold medicine in the context of herpes simplex virus (HSV) reactivation. Furthermore, we review three cases of AGEP associated with HSV infection. This report suggests HSV reactivation as a potential trigger for AGEP, emphasizing the need for caution when administering drugs to patients with HSV infection.
急性泛发性脓疱性皮病（AGEP）是一种严重的皮肤炎症，其特征为在红斑和水肿的背景上突然出现大量无菌性、非毛囊性脓疱，通常伴有发热。AGEP通常由抗生素等药物引发。然而，最近也有报道称AGEP与病毒感染之间存在关联。我们报告一例70岁男性病例，该患者在单纯疱疹病毒（HSV）激活的情况下服用非处方感冒药后发生了AGEP。此外，我们回顾了3例与HSV感染相关的AGEP病例。本报告提示HSV激活可能是AGEP的一个潜在触发因素，强调在给HSV感染患者用药时需谨慎。
