Larsh Travis R, Wu Steve W, Huddleston David A, White Sean, Lipps Tara D, Gilbert Donald L
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J Child Neurol. 2023 Apr;38(5):283-289. doi: 10.1177/08830738231171959. Epub 2023 May 8.
We aimed to compare tic- and non-tic-related impairment experienced by adolescent girls and boys (ages 13 through 17) with Tourette syndrome and associations with age. We extracted from the electronic health record child and parental responses to the mini-Child Tourette Syndrome Impairment Scale (mini-CTIM) and other questionnaire data reflective of tic- and non-tic-related impairment of adolescents with Tourette syndrome presenting to our clinic over a 12-month period. We identified a total of 132 (49 female, 83 male) unique adolescent encounters. Mini-CTIM scores did not differ significantly between genders. Tic- and non-tic-related impairment were lower in older boys, but not older girls. Obsessive-compulsive symptoms correlated with parent-reported non-tic-related impairment experienced by adolescent girls but not boys. During adolescence, tic- and non-tic-related impairments may be less likely to improve with age in girls. Future longitudinal studies are needed to confirm this finding.
我们旨在比较患有妥瑞氏症的青少年女孩和男孩（年龄在13至17岁之间）与抽动相关和非抽动相关的损伤情况，以及这些损伤与年龄的关联。我们从电子健康记录中提取了儿童和家长对儿童妥瑞氏症损伤量表简表（mini-CTIM）的回答，以及反映在12个月期间到我们诊所就诊的患有妥瑞氏症青少年抽动相关和非抽动相关损伤的其他问卷数据。我们共识别出132例（49名女性，83名男性）青少年就诊病例。Mini-CTIM评分在性别之间没有显著差异。年龄较大的男孩抽动相关和非抽动相关损伤较低，但年龄较大的女孩并非如此。强迫症状与家长报告的青少年女孩而非男孩经历的非抽动相关损伤相关。在青春期，女孩的抽动相关和非抽动相关损伤可能不太可能随年龄增长而改善。未来需要进行纵向研究来证实这一发现。
