School of Medicine, Nankai University, Tianjin 300071, China.
Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China.
J Mater Chem B. 2023 May 17;11(19):4153-4170. doi: 10.1039/d3tb00192j.
Nanozymes are a class of nanomaterials with enzyme-like activities and have attracted increasing attention due to their potential applications in biomedicine. However, nanozyme design incorporating the desired properties remains challenging. Natural or genetically engineered protein scaffolds, such as ferritin nanocages, have emerged as a promising platform for nanozyme design due to their unique protein structure, natural biomineralization capacity, self-assembly properties, and high biocompatibility. In this review, we highlight the intrinsic properties of ferritin nanocages, especially for nanozyme design. We also discuss the advantages of genetically engineered ferritin in the versatile design of nanozymes over natural ferritin. Additionally, we summarize the bioapplications of ferritin-based nanozymes based on their enzyme-mimicking activities. In this perspective, we mainly provide potential insights into the utilization of ferritin nanocages for nanozyme design.
纳米酶是一类具有酶样活性的纳米材料，由于其在生物医学中的潜在应用而引起了越来越多的关注。然而，具有所需性质的纳米酶设计仍然具有挑战性。天然或基因工程蛋白支架，如铁蛋白纳米笼，由于其独特的蛋白质结构、天然的生物矿化能力、自组装特性和高生物相容性，已成为纳米酶设计的一个有前途的平台。在这篇综述中，我们强调了铁蛋白纳米笼的固有特性，特别是在纳米酶设计方面。我们还讨论了与天然铁蛋白相比，基因工程铁蛋白在多功能纳米酶设计中的优势。此外，我们根据其模拟酶的活性总结了基于铁蛋白的纳米酶的生物应用。在这一观点中，我们主要提供了对利用铁蛋白纳米笼进行纳米酶设计的潜在见解。
