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感染的发病机制。

Pathogenic mechanism of infection.

机构信息

Department of Neurosurgery, First Naval Hospital of Southern Theater Command, Zhanjiang, 524000, China.

Department of Orthopedics, First Naval Hospital of Southern Theater Command, Zhanjiang, 524000, China.

出版信息

Future Microbiol. 2023 Apr;18:373-383. doi: 10.2217/fmb-2022-0243. Epub 2023 May 9.

Abstract

is a fatal, opportunistic human pathogen transmitted through the consumption of raw/undercooked seafood or direct contact. infection progresses rapidly and has severe consequences; some cases may require amputation or result in death. Growing evidence suggests that virulence factors and regulators play a large role in disease progression, involving host resistance, cellular damage, iron acquisition, virulence regulation and host immune responses. Its disease mechanism remains largely undefined. Further evaluation of pathogenic mechanisms is important for selecting appropriate measures to prevent and treat infection. In this review, the possible pathogenesis of infection is described to provide a reference for treatment and prevention.

摘要

创伤弧菌是一种致命的、机会性的人类病原体,通过食用生的/未煮熟的海鲜或直接接触传播。感染迅速进展,后果严重;某些情况下可能需要截肢,甚至导致死亡。越来越多的证据表明,毒力因子和调节剂在疾病进展中起重要作用,涉及宿主抵抗、细胞损伤、铁摄取、毒力调节和宿主免疫反应。其发病机制在很大程度上尚不清楚。进一步评估发病机制对于选择预防和治疗创伤弧菌感染的适当措施非常重要。本综述描述了创伤弧菌感染的可能发病机制,为治疗和预防提供参考。

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