Fonseca M I, Aguilar J S, López C, García Fernández J C, De Robertis E
Toxicol Appl Pharmacol. 1986 Jun 15;84(1):192-5. doi: 10.1016/0041-008x(86)90426-6.
In different brain regions of the rat we studied the effect of chronic feeding with the organochlorine insecticides p,p'-DDT and gamma-HCH on the cholinergic muscarinic receptors. Using [3H]quinuclidinyl benzylate binding to membranes from cerebral cortex, medulla pons, diencephalon, and cerebellum it was found that the two insecticides produced a decrease in the number of muscarinic receptor sites in cerebellum; while gamma-HCH also reduced these receptors in diencephalon. In both cases no changes in receptor affinity were observed. It is suggested that the chronic treatment with these organochlorine insecticides may cause an alteration in cholinergic transmission leading to a down regulation of the muscarinic receptor in certain brain regions.
我们研究了在大鼠的不同脑区长期喂食有机氯杀虫剂p,p'-滴滴涕和γ-六氯环己烷对胆碱能毒蕈碱受体的影响。通过使用[³H]喹核醇基苯甲酸酯与大脑皮层、脑桥延髓、间脑和小脑的膜结合，发现这两种杀虫剂使小脑中毒蕈碱受体位点的数量减少；而γ-六氯环己烷也使间脑中的这些受体减少。在这两种情况下，均未观察到受体亲和力的变化。提示长期使用这些有机氯杀虫剂可能导致胆碱能传递改变，从而导致某些脑区毒蕈碱受体下调。
