Ben-Barak J, Gazit H, Silman I, Dudai Y
Eur J Pharmacol. 1981 Aug 27;74(1):73-81. doi: 10.1016/0014-2999(81)90325-3.
Administration of the muscarinic agonist oxotremorine led to a decrease in the number of muscarinic receptors, as determined by specific binding of [3H]quinuclidinyl benzilate ([3H]QNB), in several rat brain regions both during development and at maturity. In contrast, administration of the muscarinic antagonist scopolamine led to an increase in the number of [3H]QNB-binding sites in various brain regions. Scopolamine also prevented the decrease in the number of [3H]QNB-binding sites induced by administration of an organophosphorus drug. The results are compatible with the hypothesis that the number of brain muscarinic receptors, or at least of a sub-class of them, is regulated by their transmitter.
毒蕈碱激动剂氧化震颤素的给药导致毒蕈碱受体数量减少，这是通过在发育期间和成熟时对几只大鼠脑区中[3H]喹核醇基苯甲酸酯（[3H]QNB）的特异性结合来确定的。相比之下，毒蕈碱拮抗剂东莨菪碱的给药导致各个脑区中[3H]QNB结合位点数量增加。东莨菪碱还阻止了由有机磷药物给药诱导的[3H]QNB结合位点数量的减少。这些结果与以下假设相符，即脑毒蕈碱受体的数量，或至少其中一个亚类的数量，受其递质调节。
