Bitterman N, Talmi Y, Lerman A, Melamed Y, Taitelman U
Toxicol Appl Pharmacol. 1986 Jun 30;84(2):325-8. doi: 10.1016/0041-008x(86)90140-7.
In order to evaluate the efficiency of hyperbaric oxygen in experimental acute sulfide poisoning, we studied the effect of 1 ATA (atmosphere absolute) oxygen and sodium nitrite therapy. We then studied the effect of oxygen at 3 ATA alone and in combination with intraperitoneal sodium nitrite injection on rats poisoned by intraperitoneal injection of LD75 sulfide. Electroencephalogram and heart rate were continuously monitored. We also studied the effect of sodium nitrite and hyperbaric oxygen administered before the poisoning (protective effect). In our experimental set, death of untreated poisoned animals occurred within 5 min. There is a parallel between modification of the EEG pattern and apnea. Respiratory arrest always preceded cardiac arrest. Pure oxygen (1 ATA O2) is effective in preventing death in experimental sulfide poisoning. 3 ATA oxygen was significantly more effective in preventing death than 1 ATA oxygen, or sodium nitrite alone. The best therapeutic regimen was a combination of 3 ATA oxygen and sodium nitrite administration.
为了评估高压氧对实验性急性硫化物中毒的疗效，我们研究了1个绝对大气压（ATA）的氧气和亚硝酸钠疗法的效果。然后，我们研究了单独使用3个ATA的氧气以及联合腹腔注射亚硝酸钠对腹腔注射LD75硫化物中毒大鼠的影响。持续监测脑电图和心率。我们还研究了中毒前给予亚硝酸钠和高压氧的效果（保护作用）。在我们的实验装置中，未治疗的中毒动物在5分钟内死亡。脑电图模式的改变与呼吸暂停之间存在平行关系。呼吸骤停总是先于心脏骤停。纯氧（1个ATA O2）可有效预防实验性硫化物中毒的死亡。3个ATA的氧气在预防死亡方面比1个ATA的氧气或单独使用亚硝酸钠显著更有效。最佳治疗方案是3个ATA的氧气与亚硝酸钠联合给药。
