Smith R P, Kruszyna R, Kruszyna H
Arch Environ Health. 1976 May-Jun;31(3):166-9. doi: 10.1080/00039896.1976.10667212.
Oxygen (100% at 1 atmosphere) did not protect mice against death from acute sulfide poisoning as compared with animals maintained under air at 1 atmosphere. Sodium thiosulfate had a small, but statistically significant (P less than .05) protective effect against death due to sodium sulfide, whether the mice were maintained under air or oxygen. Pretreatment with sodium nitrite, however, increased the acute intraperitoneal lethal dose for 50% survival of the group (LD50) of sodium sulfide 2.5 times. Neither oxygen, thiosulfate, nor the combination potentiated the protective effects of nitrite against sulfide poisoning. Antidotal effects of nitrite in acute sulfide poisoning were demonstrated in rats. The therapeutic efficacy of nitrite in acute poisoning is clearly superior to that of oxygen, which is the more widely recommended antidote.
与在1个大气压空气环境下饲养的动物相比，（在1个大气压下的）纯氧并不能保护小鼠免于急性硫化物中毒死亡。无论小鼠是饲养在空气还是氧气环境下，硫代硫酸钠对硫化钠所致的死亡都有轻微但具有统计学意义（P<0.05）的保护作用。然而，用亚硝酸钠预处理可使硫化钠组50%存活的急性腹腔内致死剂量（LD50）增加2.5倍。氧气、硫代硫酸钠及其组合均未增强亚硝酸盐对硫化物中毒的保护作用。亚硝酸盐在急性硫化物中毒中的解毒作用在大鼠中得到了证实。亚硝酸盐在急性中毒中的治疗效果明显优于氧气，而氧气是更广泛推荐的解毒剂。
