Zhang Yi, Zhang Yulin, Zhu Li, Yu Zixiang, Lu Fangting, Wang Zhen, Zhang Qiu
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 May 2;16:1247-1259. doi: 10.2147/DMSO.S398124. eCollection 2023.
Obesity in adults is a problem, particularly when paired with other metabolic abnormalities. Previous research have linked various screening approaches to diabetes, but additional evidence points to the relevance of combining diabetes screening methods with obesity and its effects. This research examined the impact of thyroid hormones (TSHs) and health risk factors (HRFs) in screening for obesity and diabetes in Chinese populations, and whether age can modulate this association.
From March to July 2022, the Hefei Community Health Service Center connected with the First Affiliated Hospital of Anhui Medical University was chosen, and the multi-stage cluster sample approach was utilized to test adults aged 21-90 in each community. Latent category analysis (LCA) was performed to investigate the clustering patterns of HRFs. A one-way ANOVA was used to examine waist circumference (WC), biochemical markers, and general data. Furthermore, multivariate logistic regression analysis was utilized to investigate the relationship between health risk variables and WC.
A total of 750 individuals without a history of major problems who had a community health physical examination were chosen, with missing data greater than 5% excluded. Finally, 708 samples were included in the study with an effective rate of 94.4%. The average WC was (90.0±10.33) cm, the prevalence in the >P, PP, PP, and ≤P groups were 24.7%, 18.9%, 28.7% and 27.7%, respectively. The average TSH was (2.76±2.0) μIU/mL. Male (=1.91), HOMA-IR (=0.06), TyG (=2.41), SBP (=0.08), TG (=0.94) and UA (=0.03) were more likely to have a higher prevalence of WC level. The analyses revealed significant correlations between HRFs, TSH, age, other metabolic indexes and WC ( < 0.05).
Our findings suggest that the quality of metabolic-related indicators used to successfully decrease diabetes in Chinese individuals with high HRFs levels should be prioritized. Comprehensive indicators might be a useful and practical way for measuring the metabolic evolution of diabetes level levels.
成人肥胖是一个问题，尤其是与其他代谢异常同时存在时。先前的研究已将各种筛查方法与糖尿病联系起来，但更多证据表明将糖尿病筛查方法与肥胖及其影响相结合具有重要意义。本研究探讨了甲状腺激素（促甲状腺激素）和健康风险因素在筛查中国人群肥胖和糖尿病中的作用，以及年龄是否会调节这种关联。
选取2022年3月至7月与安徽医科大学第一附属医院合作的合肥社区卫生服务中心，采用多阶段整群抽样方法对各社区21至90岁的成年人进行检测。采用潜在类别分析（LCA）研究健康风险因素的聚类模式。采用单因素方差分析来检验腰围（WC）、生化指标和一般数据。此外，利用多因素逻辑回归分析来研究健康风险变量与腰围之间的关系。
共选取750名无重大疾病史且接受社区健康体检的个体，排除缺失数据大于5%的个体。最终，708个样本纳入研究，有效率为94.4%。平均腰围为（90.0±10.33）厘米，＞P、PP、PP和≤P组的患病率分别为24.7%、18.9%、28.7%和27.7%。促甲状腺激素平均水平为（2.76±2.0）μIU/mL。男性（=1.91）、稳态模型评估胰岛素抵抗（=0.06）、甘油三酯葡萄糖指数（=2.41）、收缩压（=0.08）、甘油三酯（=0.94）和尿酸（=0.03）更易出现较高的腰围水平患病率。分析显示健康风险因素、促甲状腺激素、年龄、其他代谢指标与腰围之间存在显著相关性（＜0.05）。
我们的研究结果表明，对于高健康风险因素水平的中国个体，应优先考虑用于成功降低糖尿病风险的代谢相关指标的质量。综合指标可能是衡量糖尿病水平代谢演变的一种有用且实用的方法。
