Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland.
Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdań77sk, Poland.
Acta Biochim Pol. 2023 May 9;70(2):347-361. doi: 10.18388/abp.2020_6588.
Onco-nephrology is a new field of medicine which combines many aspects of kidney injury in cancer patients and cancers in patients with kidney disease. This connection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, numerous paraneoplastic syndromes and an increased rate cancers in dialysis and transplanted patients. The appropriate laboratory assessment of the kidney function allows to optimize chemotherapy and thus minimizes the risk of complications. This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.
肿瘤肾脏病学是一门新兴的医学领域，它结合了癌症患者肾脏损伤和肾病患者癌症的多个方面。这种联系有多种形式，包括药物性肾毒性、电解质紊乱、许多副肿瘤综合征以及透析和移植患者癌症发生率的增加。对肾脏功能进行适当的实验室评估可以优化化疗，从而最大限度地降低并发症的风险。本文重点介绍急性肾损伤 (AKI)、慢性肾脏病 (CKD)、各种电解质和酸碱紊乱、肾移植后最常见的癌症以及与 HSCT（造血干细胞移植）相关的肾脏疾病。还讨论了新型癌症治疗方法（如癌症免疫疗法和质子治疗）在移植受者中的应用可能性。
