School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, 14440, Jakarta, Indonesia.
Medical Education Unit, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Pluit Raya Rd. No. 2, 14440, North Jakarta, Indonesia.
Herzschrittmacherther Elektrophysiol. 2023 Jun;34(2):153-160. doi: 10.1007/s00399-023-00941-8. Epub 2023 May 9.
Sudden cardiac death (SCD) is one of the main causes of cardiovascular mortality and accounts for 15-20% of deaths worldwide. The current stratification strategy using depressed left ventricular ejection fraction is insufficient to stratify the risk of SCD, especially in the general population. In recent years, there has been increasing evidence showing the antiarrhythmic properties of magnesium. In this systematic review, the authors aim to determine circulating magnesium as a potential risk stratification tool for SCD.
This systematic review was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and was conducted in July 2021 with sources from Google Scholar, PubMed, Science Direct, EBSCO Medline, and ProQuest.
A total of six studies were included in this review. Three studies conducted in the general population consistently showed lower risk of SCD in populations with high circulating magnesium. There was no association between circulating magnesium level and risk of SCD in intensive cardiac care unit (ICCU) patients, whilst the results were conflicting in congestive heart failure (CHF) patients.
High circulating magnesium might have the potential to be utilized as a risk stratification tool for SCD, especially in the general population. However, further study is needed to support this evidence.
心脏性猝死（SCD）是心血管死亡的主要原因之一，占全球死亡人数的 15-20%。目前使用左心室射血分数降低来进行危险分层的策略不足以分层 SCD 的风险，特别是在普通人群中。近年来，越来越多的证据表明镁具有抗心律失常的特性。在这项系统评价中，作者旨在确定循环镁作为 SCD 的潜在危险分层工具。
本系统评价基于系统评价和荟萃分析的首选报告项目（PRISMA），于 2021 年 7 月进行，来源包括 Google Scholar、PubMed、Science Direct、EBSCO Medline 和 ProQuest。
本综述共纳入 6 项研究。三项在普通人群中进行的研究一致表明，循环镁水平高的人群发生 SCD 的风险较低。循环镁水平与重症监护病房（ICCU）患者 SCD 风险之间无关联，而充血性心力衰竭（CHF）患者的结果则存在矛盾。
高循环镁可能有潜力作为 SCD 的危险分层工具，特别是在普通人群中。然而，需要进一步的研究来支持这一证据。
